Morphometric aspects of analysis of the features of endotheliocytes remodeling of thyroid arteries and veins at the conditions of postoperative portal hypertension

Authors

Keywords:

thyroid gland, arteries, veins, endotheliocytes, postresection portal hypertension, morphometry.

Abstract

Background. Endotheliocytes of the arteries and veins of the thyroid gland play an important role in the remodeling of its vascular bed at pathological conditions, providing blood supply and drainage of venous blood. Objective. Morphometrically study the features of structural changes in endothelial cells of the arteries and veins of the thyroid gland in postresection portal hypertension. Methods. Endotheliocytes of the arteries and veins of the thyroid gland of 3 groups of white rats were morphometrically studied: 15 control animals; 30 rats with post-resection portal hypertension, 17 animals with post-resection portal hypertension and multiple organ failure. Rats were euthanized by bleeding a month after the start of the experiment under thiopental anesthesia. The area of ​​endothelial cells of the arteries and veins, their nuclei, nuclear-cytoplasmic index, and the volume of damaged endothelial cells were determined on micropreparations of the thyroid gland, Quantitative values ​​were processed statistically. Results. Postresection portal hypertension is accompanied by an uneven decrease in the area of ​​endothelial cells and their nuclei, disruption of nuclear-cytoplasmic relations, and an increase in the volume of damaged endothelial cells. Conclusion. Prolonged postresection portal hypertension in rats leads to pronounced remodeling of endothelial cells of the arteries and veins of the thyroid gland, disproportionate reduction of the areas of endothelial cells, their nuclei, changes in the relationships between them, disturbances of structural cellular homeostasis, increase in the volumes of damaged endothelial cells, endothelial dysfunction. The established structural reorganization of endothelial cells of the vascular bed of the thyroid gland under conditions of simulated pathology dominated in the venous vessels of the studied organ in combination with postresection portal hypertension with multiple organ failure.

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Published

2025-10-30

How to Cite

Hnatjuk , M., Chernetskyy , A., Tatarchuk , L., & Stets , N. (2025). Morphometric aspects of analysis of the features of endotheliocytes remodeling of thyroid arteries and veins at the conditions of postoperative portal hypertension. Морфологія / Morphologia / Morfologìâ, 19(3), 60–64. Retrieved from https://morphology.dma.edu.ua/article/view/345467

Issue

Vol. 19 No. 3 (2025)

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Статті

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