Features of the structural organisation of the liver of experimental rats 1 hour after exposure to the venom of the scorpion Leiurus macroctenus

Authors

DOI:

https://doi.org/10.26641/1997-9665.2025.3.55-59

Keywords:

venom, scorpions, morphology, liver, hepatocytes, rats.

Abstract

Background. Scorpion stings are a serious threat to human health and life in almost all countries of the world. The amount and toxicity of the poison that enters the body of the victims depend on the interspecific variability of these animals. Scorpion venom usually causes the development of local, cardiotoxic, neurotoxic and vegetative effects. Depending on the predominance of one or another component in the venom, a wide range of clinical signs and symptoms can be observed from local reactions to serious consequences, including respiratory, gastrointestinal, cardiovascular or neurological complications. Objective. Study of the features of the microscopic organisation of the liver of experimental rats 1 hour after exposure to the venom of the scorpion Leiurus macroctenus. Methods. Experimental studies were conducted on 60 male rats (180 g±3 g), which were injected intramuscularly with 0.5 ml of the poison solution (28.8 mg/ml) (LD50=0.08 mg/kg). For microscopic examination, liver tissue samples from animals of all groups were taken. Histological liver preparations were stained with hematoxylin and eosin. Results and conclusion. Microscopic studies one hour after administration of Leiurus macroctenus scorpion venom to rats demonstrated the appearance of minor shifts in the normal histoarchitectonics of the animal's liver. Hepatocytes were predominantly hexagonal in shape and contained one nucleus, but the presence of binucleated cells was noted. Infiltration of the portal tracts and sometimes the surrounding parenchyma of the organ with lymphocytes, histiocytes and neutrophils was stressed. Hepatocytes near the foci of infiltration underwent vacuolar dystrophy, which is a manifestation of reactive changes in response to the action of the venom.

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Published

2025-10-30

How to Cite

Haidai , O. (2025). Features of the structural organisation of the liver of experimental rats 1 hour after exposure to the venom of the scorpion Leiurus macroctenus. Морфологія / Morphologia / Morfologìâ, 19(3), 55–59. https://doi.org/10.26641/1997-9665.2025.3.55-59

Issue

Vol. 19 No. 3 (2025)

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