Clinical and laboratory features of the course of some acute viral infections

Authors

DOI:

https://doi.org/10.26641/1997-9665.2025.4.104-112

Keywords:

peripheral blood, clinic, Covid-19, influenza A, SFTSV, viral infections.

Abstract

Background. It is practically important to investigate pathogenetically determined clinical and laboratory characteristics of important acute respiratory viral infections. Objective. We carried out a comprehensive analysis of the data base on the peculiarities of clinical and laboratory indicators in various important acute respiratory viral infections with the understanding of their underlying pathogenetic mechanisms in order to provide clinicians with certain recommendations for how to carry out their differential diagnosis. Methods. A look at literary works from PubMed databases for the last 10 years. Results. Their differences have been established, which has practical significance. Conclusion. In 2019n –CoV infections, seasonal influenza, influenza A, SFTSV viral infections in severe cases, primarily T-cell immunity disorders occur, more so in 2019n -CoV. In SARS-CoV-2, compared with SFTSV and influenza A infection, there is hyperactivity of macrophages, which leads to a cascade of inflammatory and destructive processes in tissues, with neutrophilosis in peripheral blood, the appearance of immature forms of neutrophils and dysplastic changes in them. In SFTS infection and avian influenza (H7N9), laboratory indicators of hematopoiesis suppression with leuko-, lympho- and thrombopenia are more common than in 2019-CoV, seasonal and pandemic influenza A (H1N1).

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2025-10-30

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Korolenko , H., & Pisotska , L. (2025). Clinical and laboratory features of the course of some acute viral infections. Морфологія / Morphologia / Morfologìâ, 19(4), 104–112. https://doi.org/10.26641/1997-9665.2025.4.104-112

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Vol. 19 No. 4 (2025)

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