Topological features of the formation of the cardiomyocyte secretory apparatus in different parts of developing rat heart

Authors

DOI:

https://doi.org/10.26641/1997-9665.2025.4.81-87

Keywords:

heart, atria, ventricles, rat, ontogenesis, cardiomyocytes, secretory apparatus.

Abstract

Relevance. Despite the abundance of information about the heterogeneity of secretory atrial granules, about their uneven distribution in individual contractile cells and tissue areas of the myocardium in the atrial wall, today the morphological features of the development of the cardiomyocyte secretory apparatus depending on their localization in the organ require clarification. The purpose of the study is to determine the ultrastructural and histochemical features of the development of the cardiomyocyte secretory apparatus in different localizations of the rat heart. Methods. Using histochemical reaction to acid phosphatase and transmission electron microscopy, the state of the cardiomyocyte secretory apparatus of in the myocardium in the right and left atria and ventricles, in the right and left auricles of the heart, as well as in the interatrial septum of the rat heart at the stages of prenatal and postnatal ontogenesis was studied. Results and summary. The highest secretory activity of the mature myocardium is detected in the right auricle of the heart, which is due to the predominance of highly specialized secretory myocytes (more than 75% of the number of myocyte population). The secretory activity of the mature myocardium sections decreases in the sequence: left auricle – right atrium – left atrium – interatrial septum – interventricular septum – right ventricle – left ventricle. The development of the secretory apparatus at the stages of cardiogenesis is based on the transformations of the quantitative ratio between highly and lowly specialized secretory cardiomyocytes. The highest rates of formation of the secretory apparatus heterogeneity are characteristic of the myocardium of the right auricle of the heart; the lowest – for the interatrial septum. The ventricular myocardium has moderate secretory activity in the early postembryonic rat development; mature ventricular cardiomyocytes lose secretory activity. The definitive level of development of the secretory apparatus heterogeneity of the myocardium is reached by the end of the 1st month of postnatal rat ontogenesis.

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Published

2025-10-30

How to Cite

Tverdokhlib , I., Kanishchev , O., & Savran , N. (2025). Topological features of the formation of the cardiomyocyte secretory apparatus in different parts of developing rat heart. Морфологія / Morphologia / Morfologìâ, 19(4), 81–87. https://doi.org/10.26641/1997-9665.2025.4.81-87

Issue

Vol. 19 No. 4 (2025)

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