Some issues of the history of the establishment and perspectives of the development of theoretical and clinical medicine

Authors

DOI:

https://doi.org/10.26641/1997-9665.2024.3.181-185

Keywords:

prenatal diagnosis, fetal surgery, fetus, history, medicine.

Abstract

In recent decades, there has been a significant breakthrough in studying the embryonic and fetal periods of human development. This achievement was made possible by introducing the latest technologies, such as ultrasound scanners, computer tomography, and genetic analysis methods. Advanced capabilities of biochemical and cytogenetic analysis make it possible to study the development of the fetus in more detail, detect abnormalities in the formation of organs, and respond to possible pathologies in time, which opens new horizons for fetal surgery and perinatal medicine. Thanks to the technologies of prenatal diagnosis, the fetus is now considered a separate patient that needs special care and intervention when pathologies are detected. For example, ultrasound diagnostics in the early stages of pregnancy make it possible to detect structural defects, such as heart defects, as well as other abnormalities that occur during critical phases of development. Modern methods, including biochemical and molecular screenings, allow the identification of potential risks to the fetus's health, such as genetic mutations or chromosomal abnormalities. Critical periods of fetal development, such as organogenesis, are key to the formation of major body systems. At this time, the most serious deviations are possible, which can lead to congenital malformations. Each organ system has its critical phases of development, and violations at this time can have irreversible consequences. According to estimates, congenital malformations consistently account for 3-4 cases per 1,000 births and are the cause of perinatal losses in 20-25% of cases. This emphasizes the importance of early diagnosis and timely intervention. Fetal surgery opens up new possibilities for the treatment of congenital anomalies even before birth. This includes procedures such as the correction of spinal hernias or diaphragmatic hernias. Early intervention improves the prognosis for the fetus and reduces risks for the mother. Thus, the development of modern technologies has significantly increased the possibilities of prenatal diagnosis and therapy, which opens new perspectives in pregnancy management and fetal care.

References

  1. Tubbs RS. Anatomy learnt by dissecting is the one rock upon which all sound medicine and surgery rest. Clin Anat. 2024;37(6):603-604. DOI: 10.1002/ca.24212
  2. Ghosh SK. Cadaveric dissection as an educational tool for anatomical sciences in the 21st century. Anat Sci Educ. 2017;10(3):286-299. DOI: 10.1002/ase.1649
  3. Marom A. The birth, death, and renaissance (?) of dissection: A critique of anatomy teaching with - or without - the human body. Acad Med. 2020;95(7):999-1005. DOI: 10.1097/acm.0000000000003090
  4. Noble CA, Biesemier AP, McClees SF, Alhussain AM, Helms SE, Brodell RT. The history of the microscope reflects advances in science and medicine. Semin Diagn Pathol. 2024. DOI: 10.1053/j.semdp.2024.01.002
  5. Zampieri F, ElMaghawry M, Zanatta A, Thiene G. Andreas Vesalius: Celebrating 500 years of dissecting nature. Glob Cardiol Sci Pract. 2015;2015(5):66. DOI: 10.5339/gcsp.2015.66
  6. Ribatti D. William Harvey and the discovery of the circulation of the blood. J Angiogenes Res. 2009;1:3. DOI: 10.1186/2040-2384-1-3
  7. Gamaliya VM. [Educational and pedagogical activities of M.I. Pirogov in Ukraine (for the 200th anniversary of his birth)]. Science and Science of Science. 2010;2:127-128. Ukrainian
  8. Mavrogenis AF, Markatos K, Saranteas T, Ignatiadis I, Spyridonos S, Bumbasirevic M, et al. The history of microsurgery. Eur J Orthop Surg Traumatol. 2019;29(2):247-254. DOI: 10.1007/s00590-019-02378-7
  9. Shirbache K, Nematian H, Nabian MH. Regenerative medicine owes to microsurgery. Lab Anim Res. 2023;39(1):6. DOI: 10.1186/s42826-023-00158-3
  10. Bezinover D, Saner F. Organ transplantation in the modern era. BMC Anesthesiol. 2019;19(1):32. DOI: 10.1186/s12871-019-0704-z
  11. Kupiec-Weglinski JW. Grand Challenges in Organ Transplantation. Front Transplant. 2022;1:897679. DOI: 10.3389/frtra.2022.897679
  12. Pilch NA, Bowman LJ, Taber DJ. Immunosuppression trends in solid organ transplantation: The future of individualization, monitoring, and management. Pharmacotherapy. 2021;41(1):119-131. DOI: 10.1002/phar.2481
  13. Krezdorn N, Tasigiorgos S, Wo L, Turk M, Lopdrup R, Kiwanuka H, et al. Tissue conservation for transplantation. Innov Surg Sci. 2017;2(4):171-187. DOI: 10.1515/iss-2017-0010
  14. Lepoittevin M, Giraud S, Kerforne T, Barrou B, Badet L, Bucur P, et al. Preservation of organs to be transplanted: An essential step in the transplant process. Int J Mol Sci. 2022;23(9):4989. DOI: 10.3390/ijms23094989
  15. Jasirwan COM, Muradi A, Antarianto RD. Bio-artificial liver support system: A prospective future therapy. Livers. 2023;3(1):65-75. DOI: 10.3390/livers3010006
  16. Shanmugam DK, Anitha SC, Souresh V, Madhavan Y, Sampath S, Catakapatri Venugopal D, et al. Current advancements in the development of bionic organs using regenerative medicine and 3D tissue engineering. Materials Technology. 2023;38(1):2242732. DOI: 10.1080/10667857.2023.2242732
  17. Lemke T. Conceptualising suspended life: From latency to liminality. Theory Cult Soc. 2023;40(6):69-86. DOI: 10.1177/02632764221113737
  18. Mukhtar SF, Asari MA, Kasim F, Mohd Ismail ZI, Hadie SNH, Mohd Yusof NA, et al. Relevancy of embryology in modern medical curriculum. Educ Med J. 2023;15(4):133-137. DOI: 10.21315/eimj2023.15.4.10
  19. Ujházy E, Mach M, Navarová J, Brucknerová I, Dubovický M. Teratology - past, present and future. Interdiscip Toxicol. 2012;5(4):163-168. DOI: 10.2478/v10102-012-0027-0
  20. Flake AW, Crombleholme TM, Johnson MP, Adzick NS. Fetal surgery for life-threatening anomalies: evolution and state of the art. Clin Perinatol. 2020;47(4):761-777.
  21. Deprest J, Flake A, Gratacos E, Ville Y, Hecher K, Nicolaides K. The evolution of fetal surgery. Prenat Diagn. 2020;40(6):748-759.
  22. Maldonado-Estrada JG, Arango A, Carreno G, Cano G. Embryonic development and critical phases in organogenesis: implications for fetal surgery. J Fetal Med. 2019;6(2):67-75.
  23. Lee H, Hirose S, Bratton B, Farmer DL. Fetal surgery: the window for intervention in congenital anomalies. Am J Obstet Gynecol. 2021;224(4):342-350.
  24. Moldenhauer JS, Woodworth P. Fetal intervention: surgical management during the critical stages of development. Semin Perinatol. 2019;43(2):87-95.
  25. Ruiz-Cordero R, Hibbard JU. Prenatal diagnosis and fetal surgery: understanding the critical windows of vulnerability. Best Pract Res Clin Obstet Gynaecol. 2020;65:52-63.
  26. Saunders K, Belfort M, Olutoye O. Fetal intervention and the timing of congenital defect correction. Fetal Diagn Ther. 2020;47(1):5-15.
  27. Aman M, Sporer ME, Gstoettner C, Prahm C, Hofer C, Mayr W, et al. Bionic hand as artificial organ: Current status and future perspectives. Artif Organs. 2019;43(2):109-118. DOI: 10.1111/aor.13422
  28. Salminger S, Mayer JA, Sturma A, Riedl O, Bergmeister KD, Aszmann OC. Exoprothetischer Ersatz bei Amputationen der oberen Extremität [Exoprosthetic replacement for upper extremity amputations]. Z Orthop Unfall. 2016;154(04):411-424. German. DOI: 10.1055/s-0042-108910
  29. Zamorskii II, Khmara TV, Yuzko TA, Khodan АG. [Current tasks, moral and ethical problems of perinatal medicine]. Clinical Anatomy and Operative Surgery. 2023;22(1):70-75. Ukrainian. DOI: 10.24061/1727-0847.22.1.2023.10
  30. Semenyak AV. [Possibilities of prevention of abnormalities of fetal development]. In: [Proceedings of the scientific and practical conference with international participation Perinatal medicine in Ukraine: problems, achievements, priorities; 2019 Feb 21-22]. Chernivtsi: Medical University; 2019. p. 124-126. Ukrainian

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Published

2024-10-30

How to Cite

Zamorskyi , I., Khmara , T., Biryuk , I., Pankiv , T., & Koval , O. (2024). Some issues of the history of the establishment and perspectives of the development of theoretical and clinical medicine. Морфологія / Morphologia / Morfologìâ, 18(3), 181–185. https://doi.org/10.26641/1997-9665.2024.3.181-185

Issue

Vol. 18 No. 3 (2024)

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Статті

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