The relation of aortic dimensions and age-anthropometric data in women with Marfan syndrome

Authors

DOI:

https://doi.org/10.26641/1997-9665.2024.3.86-92

Keywords:

aorta, anatomy, computed tomography, radiology, heart, age, sex, anthropometry

Abstract

Background. The high level of morbidity and mortality from damage to the cardiovascular system remains an urgent problem of modern medicine. Women with Marfan syndrome suffer from acute aortic syndrome. Timely diagnosis and analysis of the aortic size are key in planning cardiac surgery and preventing fatal outcomes. Objective. To analyze the dimensions of the ascending aorta by computer tomography in women with Marfan syndrome and establish the correlation of the aortic diameter with age-anthropometric parameters. Methods. ECG-synchronized contrast-enhanced computed tomography, anthropometric, morphometric, mathematical and statistical methods. Materials were DICOM files of female patients with Marfan syndrome. Results. The study included women with Marfan syndrome, n=6, average age 44.33±13.08 years, average body length 1.67±0.05 m, average body weight 71.00±17.84, average mass index of the body 25.62±7.05 kg/m², the average value of the surface area of the body 1.80±0.22 m2. In women with Marfan syndrome, a direct strong correlation was established between the body mass index and the diameter of the aorta at the level of the aortic sinuses (sinus of Valsalva) (ρ= +0.82, p=0.044). This relationship is digitally confirmed by the method of linear regression (R=0.98, p<0.001). A direct strong correlation was established between the diameter of the aorta at the level of the sinotubular junction and the body weight, body surface area (ρ= +0.84, р=0.039) and a multiple correlation-regression relationship between the body mass index, body surface area and the aortic diameter at the level of the aortic sinuses (R= +0.97, p=0.04). Conclusion. In women with Marfan syndrome, a relationship was established between body mass index and aortic diameter at the level of the aortic sinuses, as well as correlation between body mass index, body surface area and the aortic diameter at the level of the sinotubular junction and aortic sinuses. The results emphasize the need for regular diagnostic monitoring of the size of the aorta in women with Marfan syndrome, taking into account age and anthropometric parameters.

References

  1. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019. J Am Coll Cardiol. 2020;76(25):2982–3021.
  2. Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1204–1222.
  3. Xuan Y, D’Souza SN, Wang Z, Pierre AS, Lawton JS, Ge L, et al. Patient-Specific Biomechanics in Marfan Ascending Thoracic Aortic Aneurysms. Ann Thorac Surg. 2021;114(4):1367-1375.
  4. Martín C, Evangelista A, Serrano-Fiz S, Villar S, Ospina V, Martínez D, et al. Aortic Complications in Marfan Syndrome: Should We Anticipate Preventive Aortic Root Surgery? Ann Thorac Surg. 2020;109(6):1850–1857.
  5. Pidvalna U, Beshley D, Mateshuk-Vatseba L, Averchuk V, Kulyk L. Anatomy of aortic dissection in the patient with marfan syndrome who underwent surgery: a case report. Proceedings of the Shevchenko Scientific Society Medical Sciences. 2020;4;59(1):116–124.
  6. Kolck J, Trippel TD, Philipp K, Gehle P, Geisel D, Beetz NL. Updated 2022 ACC/AHA Guideline Improves Concordance Between TTE and CT in Monitoring Marfan Syndrome and Related Disorders, but Relevant Measurement Differences Remain Frequent. Glob Heart. 2024;8:23.
  7. Beetz NL, Trippel TD, Philipp K, Maier C, Walter-Rittel T, Shnayien S, et al. Discrepancy of echocardiography and computed tomography in initial assessment and 2-year follow-up for monitoring Marfan syndrome and related disorders. Sci Rep. 2022;12(1):15333.
  8. Sergeta I, Gunas V, Kovalchuk V, Shipitsyna O. [Peculiarities of relationships between heart rate variability indicators and anthropo-somatotypological body parameters of practically healthy girls with different types of hemodynamics]. Morphologia. 2017;23(2):327–331. Ukrainian.
  9. Renner S, Schüler H, Alawi M, Kolbe V, Rybczynski M, Woitschach R, et al. Next-generation sequencing of 32 genes associated with hereditary aortopathies and related disorders of connective tissue in a cohort of 199 patients. Genetics in Medicine. 2019;21(8):1832–1841.
  10. Hennessey B, Vera-Urquiza R, Mejía-Rentería H, Gonzalo N, Escaned J. Contemporary use of coronary computed tomography angiography in the planning of percutaneous coronary intervention. Int J Cardiovasc Imaging. 2020;36(12):2441–2459.
  11. Narula N, Devereux RB, Malonga GP, Hriljac I, Roman MJ. Pregnancy-Related Aortic Complications in Women With Marfan Syndrome. J Am Coll Cardiol. 2021;78(9):870–879.
  12. Gietzen C, Pennig L, von Stein J, Guthoff H, Weiss K, Gertz R, et al. Thoracic aorta diameters in Marfan patients: Intraindividual comparison of 3D modified relaxation-enhanced angiography without contrast and triggering (REACT) with transthoracic echocardiography. Int J Cardiol. 2023;390:131203.
  13. van Andel MM, de Waard V, Timmermans J, Scholte AJHA, van den Berg MP, Zwinderman AH, et al. Aortic distensibility in Marfan syndrome: a potential predictor of aortic events? Open Heart. 2021;8(2):e001775.
  14. Komutrattananont P, Mahakkanukrauh P, Das S. Morphology of the human aorta and age-related changes: anatomical facts. Anat Cell Biol. 2019;52(2):109–114.
  15. Vanem TT, Geiran OR, Krohg-Sørensen K, Røe C, Paus B, Rand-Hendriksen S. Survival, causes of death, and cardiovascular events in patients with Marfan syndrome. Mol Genet Genomic Med. 2018;6(6):1114–1123.
  16. Suleiman MN, Freilinger S, Meierhofer C, May M, Bischoff G, Ewert P, et al. The relation of aortic dimensions and obesity in adults with Marfan or Loeys-Dietz syndrome. Cardiovasc Diagn Ther. 2022;12(6):787–802.

Downloads

Published

2024-10-30

How to Cite

Pidvalna , U., Beshley , D., & Mateshuk-Vatseba , L. (2024). The relation of aortic dimensions and age-anthropometric data in women with Marfan syndrome. Морфологія / Morphologia / Morfologìâ, 18(3), 86–92. https://doi.org/10.26641/1997-9665.2024.3.86-92

Issue

Vol. 18 No. 3 (2024)

Section

Статті

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.