The problem of endemic mycoses development and spread in modern conditions. Case report: aspergillosis of the maxillary sinus

Authors

DOI:

https://doi.org/10.26641/1997-9665.2024.3.50-54

Keywords:

mycosis, mycetoma, sinusitis, aspergillosis, molds.

Abstract

Background. Endemic mycoses are an important cause of morbidity and mortality in immunocompromised individuals, but the issues of prevention, diagnosis and therapy remain incompletely resolved, when there is a high probability of this pathological condition atypical forms development. Local forms of mycosis can sometimes imitate other pathology, therefore, to verify the diagnosis, it is important to conduct a pathohistological examination using specific dyes. The objective of the study is to emphasize the relevance of the development and the risk of an increase in the number of cases of endemic mycoses in modern conditions, a review of a clinical case of aspergillosis of the maxillary sinus with a comparative analysis of the results of the conducted research with data from the world literature. Methods. The post-operative material of the patient with a diagnosis of chronic right-sided maxillary sinusitis with pronounced pain syndrome was examined in the study. The obtained sections of the lesion were stained with hematoxylin and eosin according to the standard method, as well as with the use of Schiff-iodic acid (PAS reaction) in order to identify the pathogenic factor. Results. The patient had complaints of discomfort, pain and periodic swelling in the area of ​​the right maxillary sinus in combination with mucous and purulent secretions from the nasal cavity and difficult nasal breathing for a year and a half. Fluctuations in blood glucose levels in the anamnesis. During computer tomography, a rounded dense formation with clear contours, up to 1.5 cm in diameter, was detected in the right maxillary sinus. During the operation, a dense formation of yellow-brown color, rounded shape, 1.7x1.5x1 cm in size was removed. According to the results of histopathological research among the tissue elements of the removed formation revealed various growth forms of Aspergillus. Conclusion. Cavities of the human body are a substrate for the development of invasive forms of mycosis, which require the early application of modern diagnostic methods in order to verify the diagnosis. The final diagnosis depends on the detection of fungi in smears of aspirate or biopsy material. To differentiate the type of fungal pathogen, it is better to use India ink or Schiff-iodic acid (PAS reaction). It is possible to assume that global climate changes, which are expected in the future, will lead to an increase in the insemination of the macroorganism by fungal flora.

References

  1. Malcolm TR, Chin-Hong PV. Endemic mycoses in immunocompromised hosts. Curr Infect Dis Rep. 2013;15(6):536-543. DOI: 10.1007/s11908-013-0387-4
  2. Paulussen C, Hallsworth JE, Álvarez‐Pérez S, Nierman WC, Hamill PG, Blain D, Rediers H, Lievens B. Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species. Microb Biotechnol. 2017;10(2):296-322. DOI: 10.1111/1751-7915.12367
  3. Al-Dousary SH. Allergic fungal sinusitis: radiological and microbiological features of 59 cases. Ann Saudi Med. 2008;28(1):17-21. DOI: 10.5144/0256-4947.2008.17
  4. Chen CY, Sheng WH, Cheng A, Chen YC, Tsay W, Tang JL, Huang SY, Chang SC, Tien HF. Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in Taiwan. BMC Infect Dis. 2011;11:250. DOI: 10.1186/1471-2334-11-250
  5. Panjabi C, Shahcorresponding A. Allergic Aspergillus sinusitis and its association with allergic bronchopulmonary aspergillosis. Asia Pac Allergy. 2011;1(3):130-137. DOI: 10.5415/apallergy.2011.1.3.130
  6. Shetty S, Chandrashekar S, Aggarwal N. A Study on the Prevalence and Clinical Features of Fungal Sinusitis in Chronic Rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 2020;72(1):117–122. DOI: 10.1007/s12070-019-01769-w
  7. Shyrobokov VP, Klymniuk SI, Poniatovskyi VA, Bobyr VV, Vynohrad NO, Voitsekhovskyi VH, Halkin OY, Danyleichenko VV, Dziublyk IV, Dyment HS, Yevtushenko ОІ, Zadorozhna VІ, Koval HM, Kovalchuk VP, Korniichuk ОP, Kremenchutskyi HМ, Kurchenko АІ, Loban HА, Minukhin VV, Palii HK, Rudenko АV, Salamatin RV, Filimonova NI, Yankovskyi DS, authors. Medychna mikrobiolohiia, virusolohiia ta imunolohiia [Medical microbiology, virology and immunology]. Vinnytsia: Nova Knyha; 2011. 952 p. Ukrainian.
  8. Peral-Cagigal B, Redondo-González L-M, Verrier-Hernández A. Invasive maxillary sinus aspergillosis: A case report successfully treated with voriconazole and surgical debridement. J Clin Exp Dent. 2014;6(4):448–451. DOI: 10.4103/0970-9371.101171
  9. Schubert MS. Allergic fungal sinusitis: pathophysiology, diagnosis and management. Medical Mycology. 2009;47(1):324–330. DOI: 10.1080/13693780802314809
  10. Sharma D, Mahajan N, Rao S, Khurana N, Jain S. Invasive maxillary aspergillosis masquerading as malignancy in two cases: Utility of cytology as a rapid diagnostic tool. J Cytol. 2012;29(3):194–196. DOI: 10.4103/0970-9371.101171
  11. Soontrapa P, Larbcharoensub N, Luxameechanporn T, Cheewaruangroj W, Prakunhungsit S, Sathapatayavong B, Chongtrakool P, Leopairut J. Fungal rhinosinusitis: a retrospective analysis of clinicopathological features and treatment outcomes at Ramathibodi hospital. Southeast Asian J Trop Med Public Health. 2010;41(2):442–449. PMID: 20578529

Downloads

Published

2024-10-30

How to Cite

Korolenko , H., Usova , O., Bondarenko , O., & Bakaiev , A. (2024). The problem of endemic mycoses development and spread in modern conditions. Case report: aspergillosis of the maxillary sinus. Морфологія / Morphologia / Morfologìâ, 18(3), 50–54. https://doi.org/10.26641/1997-9665.2024.3.50-54

Issue

Vol. 18 No. 3 (2024)

Section

Статті

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.