Pathomorphological features of the ultrastructure in the smooth muscle walls of rat eye vessels during the chronic phase of streptozotocin-induced diabetes

Authors

DOI:

https://doi.org/10.26641/1997-9665.2022.4.47-50

Keywords:

eye, blood vessels, microcirculation, angiopathy, diabetes, experiment, rat.

Abstract

Background. The development of angiopathy in diabetes mellitus represents a significant manifestation of profound metabolic disturbances associated with this condition, leading to various severe complications that contribute to functional impairment and, over time, may result in disability. Diabetes induces significant alterations in the tissues of the eyeball, and while extensive information exists regarding the vascular implications of chronic damage to the membranes of the eyeball, it remains inconsistent. Investigating the dynamics of pathomorphological changes in smooth muscle cells within the eye’s vascular structures during the progression of experimental streptozotocin-induced diabetes continues to be a pressing issue. The aim of our research was to examine the ultrastructural features related to the disorganization of smooth muscles in the walls of rat eye vessels during the chronic phase of experimental streptozotocin-induced diabetes. Methods. The study was conducted on 20 mature, outbred white male rats, weighing 120-130 g. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin from the Sigma company at the rate of 7 mg per 100 g of body weight. The research was conducted from the sixth week of the experiment on animals with a glucose level of more than 16.00 mmol per 1 liter. 2 groups of animals were used in the work: 1 group (15 animals) with diabetes that developed (6 weeks after administration of streptozotocin); Group 2 was the control group (5 animals), received injections of 0.9% physiological solution for 6 weeks. Results and conclusion. The conducted studies showed that there is a certain correlation between ultrastructural changes with subsequent impairment of the function of vessel walls and the occurrence of consequences as a manifestation of diabetic angiopathy. The indicated damage to the ultrastructure of the cell membranes of smooth muscle cells forms the basis for the occurrence of a violation of the contractile function of the cell apparatus with a subsequent violation of the ability to relax. Understanding this pathomorphism in the future will form the basis of drug correction of the resulting consequences. The results of our study indicate that, hypothetically, in addition to disorders in smooth muscle cells during the development of experimental streptozotocin-induced diabetes, some compensatory adaptive mechanisms also occur. The described morphofunctional changes in the structure of smooth muscle cells may be one of the links in the pathogenesis of diabetic angiopathy, which is characteristic of the course of diabetes.

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Published

2022-12-15

How to Cite

Tverdokhlib , I., Smolkova , O., & Ambarova , N. (2022). Pathomorphological features of the ultrastructure in the smooth muscle walls of rat eye vessels during the chronic phase of streptozotocin-induced diabetes. Морфологія / Morphologia / Morfologìâ, 16(4), 47–50. https://doi.org/10.26641/1997-9665.2022.4.47-50

Issue

Vol. 16 No. 4 (2022)

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Статті

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