Current trends in the use of liquid cytology for the analysis of neoplasia of various genesis

Authors

DOI:

https://doi.org/10.26641/1997-9665.2024.2.6-21

Keywords:

liquid cytology, traditional cytology, neoplasia, mammary and thyroid glands, urine sediment, aspirate fluids, bronchoalveolar secretion.

Abstract

Actuality. The review highlights the peculiarities of preparation and analysis of samples of various biological materials using the liquid-based cytology (LBC) method. Morphological characteristics of different clinical materials obtained by LBC and traditional cytology (TC) methods are presented and compared. Several LBC slide preparation technologies are discussed and compared in the study: BD SurePath, ThinPrep, and HurePath. It is demonstrated that materials obtained by the LBC method do not contain clusters of hematogenous and locally derived cellular elements, which interfere with assessing their qualitative and quantitative changes. Objective. To identify all the advantages and disadvantages of using LBC technologies compared to TC for the analysis of benign and malignant neoplasia of various genesis. Conclusion. The expediency of using RC for the study of squamous epithelial neoplasia: urine sediment, sputum secretions, and effusions has been proved. It is recommended to use RC technology with caution when analysing material with glandular, follicular or parafollicular structure, as changes in the morphological characteristics of neoplasms can lead to erroneous cytomorphological findings. In order to improve the quality of this type of material assessment, it is suggested to use both LBC and TC methods simultaneously.

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2024-07-30

How to Cite

Lozovskaya , Y. (2024). Current trends in the use of liquid cytology for the analysis of neoplasia of various genesis. Морфологія / Morphologia / Morfologìâ, 18(2), 6–21. https://doi.org/10.26641/1997-9665.2024.2.6-21

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Vol. 18 No. 2 (2024)

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