Pathways and mechanisms of cell cycle regulation in cardiomyocytes

Authors

  • I.S. Khripkov Dnipro State Medical University, Dnipro, Ukraine https://orcid.org/0000-0003-0378-8414
  • A.A. Golikova Dnipro State Medical University, Dnipro, Ukraine
  • D.O. Sutyrin Dnipro State Medical University, Dnipro, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2023.3.174-183

Keywords:

micro-RNA, cardiomyocytes, proliferation.

Abstract

Diseases of the cardiovascular system occupy a leading place among morbidity and mortality in all countries of the world. Understanding the cellular mechanisms of development, functioning and compensatory-adaptive changes of the cardiovascular system has become indispensable both for fundamental research and for attempts to invent new and more effective methods of treatment. In our opinion, a promising direction of influence on the processes of cell cycle regulation in static cell populations is the use of micro-RNA, which involve several intracellular molecular mechanisms in the realization of their effect. Micro-RNAs (miRNAs) are short, single-stranded, non-coding RNAs that regulate gene expression at the post-transcriptional level. Generally, miRNAs negatively regulate gene expression by interacting with the 3′ untranslated region (NTO) of specific target mRNAs in sequence. MiRNAs play an important role in the prenatal and postnatal heart. Cardiac deletion of the Dicer gene, which is required to process pre-miRNA into active mature forms, leads to embryonic mortality due to developmental defects and cardiac dysfunction. Targeted removal of cardio- and skeletal-muscle-specific miRNA-1 in mice has shown that a subtle change in the dosage of this miRNA leads to a striking abnormality in the cell cycle in cardiomyocytes and has a profound effect on heart development and maintenance. It has recently been reported that cardiomyocyte proliferation can be stimulated by exogenous siRNA administration, which adds a new dimension to the regulation of cardiomyocyte proliferation. Previous studies have shown that miRNA-204 regulates the division and differentiation of human progenitor cells into cardiomyocytes. Experiments have also shown both in vitro and in vivo models support the critical involvement of miRNA-204 in cardiomyocyte proliferation. The pro-proliferative effects of miRNA-204 overexpression on cardiomyocytes were mediated through the Jarid2 signaling pathway.

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Published

2023-10-31

How to Cite

Khripkov , I., Golikova , A., & Sutyrin , D. (2023). Pathways and mechanisms of cell cycle regulation in cardiomyocytes. Морфологія / Morphologia / Morfologìâ, 17(3), 174–183. https://doi.org/10.26641/1997-9665.2023.3.174-183

Issue

Vol. 17 No. 3 (2023)

Section

Статті

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