Features of presentation of the structure of the human spleen in the course of histology

Authors

  • O.Yu. Pototska
  • K.M. Shevchenko

Keywords:

human spleen, species-specific features, opened blood supply, white pulp, marginal sinus

Abstract

ABSTRACT. Lymphoid organs are characterized by a large number of species-specific features, which depend on the size of the body, the level of physical activity, the nature of the diet and many other factors. Therefore, there are lots of contradictory scientific articles, in which authors compare organs of this system without taking into account the species of the studied animals, or extrapolate the obtained data to humans, which inevitably leads to confusion. Spleen is an important organ of immune system, since it filters blood from foreign antigens, produces antibodies and pro-inflammatory cytokines during systemic inflammatory diseases. There are many controversies about spleen structure in the scientific literature, in particular about the system of its blood supply. Some authors state that spleen has a combination of opened and closed blood capillaries, while others claim that blood circulation in human spleen is completely opened. The presence of marginal sinus as well as perimarginal cavernous sinus in the respective zone of white pulp is also the subject of debate. According to the recent discoveries made with the help of immunocytochemistry and three-dimensional modeling such terms as “periarterial macrophage sheaths" or “vagina periarteriolaris macrophagocytica” and “cords of Billroth” are revised and reconsidered. Another relevant question is the possibility of human spleen to store a reserve portion of blood and to inject it to the bloodstream during the physical activity, stress or after the massive hemorrhage. In this review, we have analyzed species-specific features of human spleen structure and functions to answer all above mentioned controversial questions. Correlations between the innervation and immune processes have also been reviewed.

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Published

2023-06-26

How to Cite

Pototska , O. ., & Shevchenko , K. . (2023). Features of presentation of the structure of the human spleen in the course of histology. Морфологія / Morphologia / Morfologìâ, 15(4), 121–129. Retrieved from https://morphology.dma.edu.ua/article/view/282957

Issue

Vol. 15 No. 4 (2021)

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