Pathomorphological changes in renal disease in patients with co-infection with human immunodeficiency virus viral hepatitis C in predicting the morphogenesis of immunocomplex diseases

Authors

Abstract

Background. Patients with HIV viral hepatitis C co-infection are subject to a significantly higher risk of various forms of virus-induced nephropathy with a wide morphological spectrum. One of the least studied aspects of the development of chronic kidney disease is a morphological substrate at different stages of its morphogenesis, in particular for a group of immunocomplex lesions. Aim. To describe the pathomorphological changes in the glomerular, tubular, interstitial components of the kidneys among 2 groups of patients with co-infection HIV/ viral hepatitis C, divided by antiretroviral therapy, to assess the role of each of the viruses and predict the morphogenesis of immunocomplex diseases. Methods. A criterion description was carried out with subsequent statistical processing of the data obtained from 40 specimens of the kidneys of patients with HIV hepatitis C co-infection in accordance with the study design. Standard histological, histochemical, and immunohistochemical stains were used. Results. Systematization and analysis of the data obtained reveal a direct dependence of the severity of sclerotic changes in the renal parenchyma on the presence of antiretroviral therapy and the level of immunosuppression in patients with HIV viral hepatitis C co-infection lesions, associated with viral hepatitis C. Conclusion. For the preservation of renal function and quality of life, patients with HIV viral hepatitis C co-infection are recommended to prescribe not only antiretroviral therapy but also specific antiviral therapy for viral hepatitis C.

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Published

2023-06-26

How to Cite

Gorodetska, . A. (2023). Pathomorphological changes in renal disease in patients with co-infection with human immunodeficiency virus viral hepatitis C in predicting the morphogenesis of immunocomplex diseases. Морфологія / Morphologia / Morfologìâ, 15(4), 33–39. Retrieved from https://morphology.dma.edu.ua/article/view/282850

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Vol. 15 No. 4 (2021)

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