Features of morphological organization of periodontal tissues during experimental drug correction against the background of weekly action of opioid analgesic

Authors

  • V.B. Fik
  • I.V. Chelpanova
  • R.M. Matkivska

Keywords:

rats, opioid, periodontium, correction, histological examination.

Abstract

Background. Various diseases of the oral cavity, tissues of the periodontal complex and teeth are quite common in opioid addicts, therefore, the development of effective treatment of such patients is of great scientific and practical interest and is an urgent problem today. Objective. To determine the effectiveness of pentoxifylline and ceftriaxone in periodontal damage on the background of experimental opioid exposure for six weeks. Methods. Studies were performed on 24 white male rats, which were divided into three groups. Group I - control rats (6). In group II, animals (9) were administered the intramuscular opioid analgesic nalbuphine for six weeks, in gradually increasing doses (0.212 mg / kg to 0.252 mg / kg). Group III - rats (9) were administered nalbuphine for six weeks, as well as drug correction with pentoxifylline (3-6 weeks) and ceftriaxone (5-6 weeks), at a dosage of 2.86 mg. Components of the dental organ of the upper and lower jaws of rats were used for histological examinations. Results. At the microstructural level, the recovery of the components of the gingival mucosa, periodontium and microcirculation was determined, which indicated the activation of compensatory-adaptive reactions. Signs of gum epithelial regeneration, preservation of collagen fiber architecture and signs of angiogenesis, as well as reduction of manifestations of edema, dystrophic changes and hypervascularization in periodontal connective tissue were noted. Conclusion. The performed drug correction with the use of pentoxifylline and ceftriaxone on the background of six weeks of opioid exposure contributed to the positive dynamics of microstructural rearrangement of rat periodontal components, which indicated an active course of reparative processes and improved hemomicrocirculation.

References

  1. Brejchova J, Holan V, Svoboda P. Expression of Opioid Receptors in Cells of the Immune System. Int J Mol Sci. 2020;22(1):315. Doi: 10.3390/ijms22010315.
  2. Bedene A, van Dorp ELA, Faquih T, Cannegieter SC, Mook-Kanamori DO, Niesters M, van Velzen M, Gademan MGJ, Rosendaal FR, Bouvy ML, Dahan A, Lijfering WM. Causes and consequences of the opioid epidemic in the Netherlands: a population-based cohort study. Sci Rep. 2020;10(1):15309. Doi: 10.1038/s41598-020-72084-6.
  3. Erim D, Obadan-Udoh E, Agaku I. Cost savings from averted prescription opioidattributable dental diseases in the United States between 2013 and 2019. Popul. Med. 2021;3:13. Doi: 10.18332/popmed/136488.
  4. Béliveau A, Castilloux AM, Tannenbaum C, Vincent P, de Moura CS, Bernatsky S, Moride Y. Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study. CMAJ Open. 2021;9(1):E96-E106. Doi: 10.9778/cmajo.20200076.
  5. Petrushanko TO, Boichenko OM, Popovych IYu, Gryshchenko VV. The tate of Oral Cavity in the Drug-Depedent Patients. World of medicine and biology. 2021; 3(77):148-151. Doi: 10.26724/2079-8334-2021-3-77-148-
  6. Sun D, YeT, Ren P, YuS. Prevalence and etiology of oral diseases in drug-addicted populations: a systematic review. International Journal of Clinical and Experimental Medicine. 2018;11(7):6521-31.
  7. Fedun IR, Furdychko AI, Ilchyshyn MP, Barilyak A. Ya., Gan IV, Vozny OV. [Influence of drug addiction on pathology of the oral cavityand features of providing dental care to drug addicts (literature review)]. Zaporizhzhia Medical Journal. 2020;22(123):858-64. DOI:10.14739/2310-1210.2020.6.218473. Ukrainian.
  8. Buchkovska AYu, Nakonechna OV, Petryshyn OA, Strus KhI. [Ultrastructural study of the gingival mucosa in generalized periodontitis]. World of medicine and biology. 2018;4:145-8. Doi: 10.26724/2079-8334-2018-4-66-145-148. Ukrainian.
  9. Arora PC, Ragi KGS, Arora A, Gupta A. Oral Health Behavoir and Treatment Needs among Drug Addicts and Controls in Amristar District: A Case-controlled Study. Journal of Neurosciences in Rural Practice 2019;10(2):201-6. Doi: 10.4103/jnrp.jnrp_309_18.
  10. Fik VB, Fedechko YM, Paltov YeV. Characteristics of the microbiome of the neck region of the teeth in the experimental action of opioid, its cancellation and application of ceftriaxone as a composition of complex medical correction. Science Review. 2020;8(35):1-5. Doi:10.31435/rsglobal_sr/30122020/7320.
  11. Dana R, Azarpazhooh A, Laghapour N, Suda KJ, Okunseri C. Role of dentists in prescribing opioid analgesics and antibiotics: an overview. Dental Clinics of North America. 2018;62(2):279-94. Doi: 10.1016/j.cden.2017.11.007.
  12. Spivak ES. Antibiotic Use in Dentistry-What We Know and Do Not Know. JAMA Netw Open. 2019;2(5):e193881. Doi: 10.1001/jamanetworkopen.2019.3881.
  13. Batig VM. Long-nerm results of complex treatment with chronic generalized periodontitis and a predominance of the sympathetic autonomic nervous system. Deutscher Wissenschaftscherold. German Science Herald. 2019;4:14-9. DOI:10.19221/201943.
  14. Babay OM [Methodology and experience in assessing the effectiveness of treatment of patients with generalized periodontitis according to ultrastructural analysis of the gum epithelium]. Ukrainian Journal of Extreme Medicine named after GO Mozhaeva. 2016;17(2):5-10. Ukrainian.
  15. González-Pacheco H, Amezcua-Guerra LM, Sandoval J, Arias-Mendoza A. Potential usefulness of pentoxifylline, a non-specific phosphodiesterase inhibitor with anti-inflammatory, anti-thrombotic, antioxidant, and anti-fibrogenic properties, in the treatment of SARS-CoV-2. Eur Rev Med Pharmacol Sci. 2020;24(13):7494-6. Doi: 10.26355/eurrev_202007_21921.

Downloads

Published

2022-06-18

How to Cite

Fik, . V. ., Chelpanova , I. ., & Matkivska , R. (2022). Features of morphological organization of periodontal tissues during experimental drug correction against the background of weekly action of opioid analgesic. Морфологія / Morphologia / Morfologìâ, 16(2), 44–50. Retrieved from https://morphology.dma.edu.ua/article/view/282018

Issue

Vol. 16 No. 2 (2022)

Section

Статті

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.