Morphometric aspects of studying of the structures of the large intestine in resections of different volumes of the liver

Authors

  • M.S. Hnatjuk
  • N.Ya. Monastyrska
  • L.V. Tatarchuk
  • O.M. Protsailo
  • O.B. Yasinovskyi
  • S.O. Konovalenko

Keywords:

liver resection, large intestine, morphometry.

Abstract

Removal of significant volumes of the liver leads to portal hypertension and damage to the organs of the digestive system. Objective. Morphometrically study the peculiarities of the morphological reconstruction of the structures of the large intestine during resections of different volumes of the liver parenchyma. Methods. Large intestine of 80 white rats, divided into 3 groups, were morphometrically studied. Group 1 – 20 intact animals, 2 – 30 rats after resection of the left lateral lobe of the liver (31.5 % of the volume), 3 – 30 animals after removal of the right and left lateral lobes of the liver (58.1 % of the volume). Euthanasia was performed by bloodletting under anesthesia a month after the start of the experiment. The thickness of its membranes, the size of epitheliocytes, their nuclei, the relative volumes of epitheliocytes, microvessels, the ratio between them, and the relative volume of damaged epitheliocytes were determined on micropreparations of the intestine. Quantitative indicators were processed statistically. Results. The resection of 58.1 % of the liver parenchyma led to postresection portal hypertension, uneven, disproportionate changes in the morphometric parameters of the large intestine membranes, violations of the relationship between them, vascular disorders, dystrophy, necrobiosis of epitheliocytes, myocytes, stroma, endotheliocytes, infiltration, sclerosis. Conclusion. Resection of 58.1 % of the liver parenchyma leads to postresection portal hypertension and pronounced remodeling of the structures of the large intestine, which is characterized by venous congestion, uneven, disproportionate changes in the morphometric parameters of its membranes, changes in the relationship between them, a decrease in capillary-epitheliocyte release, a violation of structural cellular homeostasis, an increase in the relative volume of damaged epitheliocytes, damage to myocytes, stromal structures, endotheliocytes, the development of infiltration, sclerosing.

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Published

2022-10-22

How to Cite

Hnatjuk, . M. ., Monastyrska, . N. ., Tatarchuk , L. ., Protsailo, . O. ., Yasinovskyi , O. ., & Konovalenko , S. . (2022). Morphometric aspects of studying of the structures of the large intestine in resections of different volumes of the liver. Морфологія / Morphologia / Morfologìâ, 16(3), 139–142. Retrieved from https://morphology.dma.edu.ua/article/view/282005

Issue

Vol. 16 No. 3 (2022)

Section

Статті

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