Changes in the parenchyma of the spleen under the action of monosodium glutamate and correction

Authors

Keywords:

monosodium glutamate, spleen, white pulp, red pulp, melatonin.

Abstract

Background. Given the fact that monosodium glutamate is one of the most common food additives, its effect on the organs of the immune system, as well as the possibility of correcting the changes caused by it, is a primary task for morphologists. The purpose of the study is to study the morphometric and histological changes in the spleen parenchyma of rats under the condition of a high-calorie diet and correction with melatonin. Methods and results. The study was conducted on 42 white female and male rats of reproductive age. The microanatomy of the structural components of the spleen of white rats under physiological conditions was studied on 10 intact animals. Experimental animals are divided into 2 groups. After six weeks of monosodium glutamate action, stagnation phenomena were observed, numerous macrophages with hemosiderin remnants in their cytoplasm, a large number of necrotically changed cells, vessels with a damaged wall were found, which led to the release of formed blood elements into the parenchyma of the organ. After six weeks of exposure to monosodium glutamate followed by two weeks of melatonin, it was found that the number of lymphoid nodules with a clear germinal center decreased, the trabeculae were thickened, they contained dilated full-blooded splenic arteries, and the density of lymphoid cells in the white pulp of the spleen was significantly lower than in animals of the intact group. Compared with animals receiving monosodium glutamate for six weeks, the amount of lipids and hemosiderin in dilated sinuses of the spleen decreased, the number of erythrocytes in the splenic cords and venous sinuses of the spleen, and the proportion of reticular connective tissue in the splenic cords slightly decreased. Conclusion. After six weeks of exposure to monosodium glutamate, destructive and degenerative changes occur, which become less pronounced after two weeks of melatonin correction.

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Published

2022-10-12

How to Cite

Mateshuk-Vatseba L.R. , . L. ., Holovatskyi, . A., Harapko , T. ., Foros , A., & Petrychko О. . (2022). Changes in the parenchyma of the spleen under the action of monosodium glutamate and correction. Морфологія / Morphologia / Morfologìâ, 16(3), 69–75. Retrieved from https://morphology.dma.edu.ua/article/view/281912

Issue

Vol. 16 No. 3 (2022)

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