Qualitative changes in the ultrastructure of the myocardium of rat embryos during the 16-20th day of prenatal development in normal conditions and after ethanol exposure

Authors

DOI:

https://doi.org/10.26641/1997-9665.2022.4.13-18

Keywords:

ethanol, myocardium, myofibrils, mitochondria, contractile apparatus, T-system

Abstract

Background. Violation of the formation of the components of the cardiovascular system even in the embryonic period can be caused by various endo- and exogenous factors, which in the future can lead to both the development of heart defects and deaths. Therefore, at present, with the help of many research works on the mechanism of myofibrillogenesis in cardiomyocytes (CMC), the attention of researchers has been drawn to the question of the main changes that occur in the structure of the main elements of the contractile apparatus under the influence of various teratogenic factors. The use of a powerful complex of research methods in the disclosure of this issue led to significant research in the analysis of this topic. The aim of the study was to compare the changes in the ultrastructure of the contractile apparatus of rat cardiomyocytes during the late stages of prenatal development during normal development and after the teratogenic effect of ethanol. Results and conclusion. The article is devoted to the analysis of changes in the ultrastructure of the ventricular myocardium of rat embryos during late prenatal development. Electron-microscopic methods were used for this study, followed by analysis of electrongrams. Research results indicate that alcohol intoxication led to destructive changes in the structure of the contractile apparatus of cardiomyocytes (CMC) during the entire development of rat embryos. Electron microphotographs revealed the main changes in the ultrastructure of the A- and I-discs of myofibrils, violations of the integrity of sarcomeres, changes in the shape of intercalated discs and the Z-disc. This article also draws attention to changes in the structure of triad elements, mitochondria, both in normal conditions and after exposure to ethanol.

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Published

2022-12-15

How to Cite

Marchenko , D., & Cherkas , O. (2022). Qualitative changes in the ultrastructure of the myocardium of rat embryos during the 16-20th day of prenatal development in normal conditions and after ethanol exposure. Морфологія / Morphologia / Morfologìâ, 16(4), 13–18. https://doi.org/10.26641/1997-9665.2022.4.13-18

Issue

Vol. 16 No. 4 (2022)

Section

Статті

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