Carbon-carbon composite nail for intramedullary osteosynthesis in rats with experimental osteoporosis

Authors

DOI:

https://doi.org/10.26641/1997-9665.2021.3.57-61

Keywords:

rat, tibia, femur, fracture, osteoporosis, osteosnthesis, carbon-carbon composite nail

Abstract

Background. In Ukraine, there has recently been an increase in the number of limb bone fractures among the population, in particular, due to increase in the number of elderly people, which is associated with the development of age-related osteoporosis and fragility of bones. Therefore, the use of artificial implants in traumatology is becoming increasingly important. The search for new bioinert and biodegradable materials, that are capable of providing rapid fracture consolidation and do not require repeated surgical intervention, continues. Objective. To elaborate a model for the research of using carbon-carbon composite nail for intramedullary osteosynthesis in laboratory rats with fractures of femur and tibia in norm and with experimental osteoporosis. Methods. The work investigated the lower limbs of 6 groups of Wistar rats. The first part of the study involved 4 groups of rats with modeled tibial fracture with subsequent osteosynthesis in norm and with experimental osteoporosis. The second part of the research included two groups of laboratory rats with modeled femur fracture. In both parts we used metal injection needle, as well as carbon-carbon composite nail for osteosynthesis. Results. All animals underwent surgery well, stepped on the injured limb. X-ray examination after the osteosynthesis demonstrated satisfactory reposition of the fragments. One month after modeled fracture in rats with experimental osteoporosis a violation of the normal consolidation of the fracture was observed, especially in the group where carbon-carbon composite nails were used for osteosynthesis. Further, until the 180th day after the surgery there were no peculiarities, function of the limbs was restored, mainly without expressed angular deformities. Conclusion. The above mentioned model was successfully elaborated for the research of using carbon-carbon composite nail for intramedullary osteosynthesis in laboratory rats with fractures of femur and tibia in norm and with experimental osteoporosis.

References

  1. Zavhorodnii AS. [Complex treatment of patients with compression fractures of vertebral bodies on the background of systemic osteoporosis]. In: [Medicine of the third millennium: a collection of abstracts of the interuniversity conference of young scientists and students; 2017 January 16-17; Kharkiv]. Kharkiv: KNMU; 2017. p. 179-180. Ukrainian.
  2. Rosen CJ. Pathogenesis of osteoporosis. Best Practice & Research Clinical Endocrinology & Metabolism. 2000;14(2):181–93.
  3. Golovakha ML, Chornyi VN, Yatsun EV, Tertyshnyi SI, Dikii KL. [Bone tissue regeneration during osteosynthesis with implants made of magnesium-based alloys in experiment]. Orthopedics, traumatology and prosthetics. 2013;2:45-50. Russian.
  4. Radchenko VA, Dedukh NV, Malyshkina S, Bengus LM. [Bioresorbable polymers in orthopedics and traumatology]. Orthopedics, traumatology and prosthetics. 2006;3:116-124. Russian.
  5. Pohorielov MV. [Mineral metabolism of injured bone in norm and in violation of water-salt balance]. Morphologia. 2009;3(3):90-94. Ukrainian.
  6. Daniels AU, Chang MK, Kirk PA. Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone. J. Appl. Biomat. 2004;1(1):57-78.
  7. Hryhorieva OA, Pivtorak VI, Popovych YI, Abrosimov YY, Tavrog ML. Peculiarities of synoviocytes and chondrocytes proliferative activity in rats with experimental model of undifferentiated dysplasia of connective tissue. World of Medicine and Biology. 2021;17(76):198-202. DOI:10.26724/2079-8334-2021-2-76-198-202.
  8. Maslennikov SO, Golovakha ML, Chornyi VN. [Study of the degree of integration of soft tissues into elements made of carbon-carbon composite material in the zone of transition of the internal and external environment during implantation of endo-exoprostheses]. Trauma. 2017;18(1):39-44. Russian.
  9. Sigurdsen UE, Reikeras O, Utvag SE. External fixation compared to intramedullary nailing of tibial fractures in the rat. Acta Orthop. 2009;80(3):375‐379. DOI:10.3109/17453670903035567
  10. Yuce HB, Toker H, Ozdemir H, Goze F. Effects of two experimental models of osteoporosis on alveolar bone: histopathologic and densitometric study. Oral Health Dent Manag. 2014;13(4):915-920.

Downloads

Published

2021-12-25

How to Cite

Carbon-carbon composite nail for intramedullary osteosynthesis in rats with experimental osteoporosis. (2021). Морфологія / Morphologia / Morfologìâ, 15(3), 57–61. https://doi.org/10.26641/1997-9665.2021.3.57-61

Issue

Vol. 15 No. 3 (2021)

Section

Статті

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.