Morphological characteristic of premature infants’s kidneys with opened Ductus Arteriosis (by the autopsy).

Authors

DOI:

https://doi.org/10.26641/1997-9665.2021.1.28-38

Keywords:

morphogenesis of kidney, premature infants, opened Ductus Arteriosus

Abstract

Background. Kidney has protracted nephrogenesis and depend on hemodynamic changes on the highest level in support of natural transition to extrauterine circulation. Fetal communications like Ductus Arteriosus take part in the shunting from the aorta to the pulmonary artery. Increase of this shunting of the blood leads to hyperperfusion with hypoxic changes of some development systems of organs with protracted morphogenesis so like kidneys. Objective. To determine the features of postnatal morphogenesis of the kidneys in premature infants with a gestational age of 25 to 35 weeks on the background of an open ductus arteriosus. Methods. 21 autopsy material premature infant’s kidney which were fixed by 10%-formalin and then were subjected to the standard histological procedures. Slides were stained by hematoxylin and eosin. We used the complex of histological and morphometric methods. There were created 3-demenshional models of kidney’s fragments. We carried out biometrical and statistical analysis. Results. During our research it was determines that the changes of the volume of the functional parenchyma of the kidney and the diameter of the Ductus Arteriosus became in inverse relationship. The wider the duct the smaller the volume of the functional parenchyma because of atrophic and necrotic changes during the late stages of glomerulo- and tubulogenesis. These changes could be distinguished by the quantitative density of development on three germinate layers of the cortex of kidney. Сonclusion. Summing up, it determined the retardation of glomerulogenesis particularly superficial area of the cortex because of the opened Ductus Arteriosus.

References

  1. Carmody JB, Charlton JR. Short Term Gestation, Long Term Risk: Prematurity and Chronic Kidney Disease. Pediatrics. 2013;131:1168-1179.
  2. Sutherland MR, Gubhaju L, Moore L, Alison LK, Jane ED, Rosemary SCH, Wendy EH, John FB, Black MJ. Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney. JASN. 2011;22(7):1365-1374. DOI: https://doi.org/10.1681/ASN.2010121266
  3. Rios DR, Bchattachariya S, Levi F, Mak-Namara PD. Circulatory insufficiency and hypotension, related with a function of the newborn’s opened Ductus Arteriosis. Neonatalogy: News. Opinion. Training. 2018;2(20):37-51. Doi:10.24411/2308-2402-2018-00017
  4. Gillam-Krakauer M, Reese J. Diagnosis and Management of Patent Ductus Arteriosus. NeoReviews. 2018;19(7):394–e402. Doi:10.1542/neo.19-7-e394
  5. Rodriguez MM, Gomez AH, Abitbol CL, Chandar JJ, Duara S. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatric Developmental Pathology. 2004;7:17-25.
  6. Faa G, Gerosa C, Fanni D, Nemolato S, Locci A, Cabras T, Marinelli V, Puddu M, Zaffanello M, Monga G, Fanos V. Marked interindividual variability in renal maturation of preterm infants: Lessons from autopsy. J Matern Fetal Neonatal Med. 2010;23(3):129-133.
  7. Huang HP, Tsai IJ, Lai YC, Cheng CH, Tsau YK. Early postnatal renal growth in premature infants. Nephrology. 2007;12:572-575.
  8. Gubhaju L, Sutherland MR, Yoder BA, Zulli A, Bertram JF, Black MJ. Is nephrogenesis affected by preterm birth? Studies in a non-human primate model. Am J Physiol Renal Physiol. 2009;297:1668-1677.
  9. Kursin LM., Nekludov YuA, Efimov AA [Morphological rating structural changes of human’s kidney in the age aspect]. Modern problems of the science and education. 2012;2:13-26. Russian.
  10. Tverdokhlib IV [Dimentional reconstruction of the biological objects via computer modeling]. Morphology. 2007;1(1):135-139. Ukrainian.
  11. Avtandilov HH, author. Medicinskaya morphometriia. Rukovodstvo. [Medical morpometry. Manual] Мoscow: Medcine; 1990. 384 p. Russian.
  12. Ansari AR, Bradley RA [Rank-Sum Tests for Dispersions]. Annals of mathematical statistics. 1960;31(4):1174-1189.
  13. Majed B, Bateman DA, Majed LFB, Uy N. Patent ductus arteriosus is associated with acute kidney injury in the preterm infant. Pediatr Nephrol. 2019;34(6):1129-1139. doi: 10.1007/s00467-019-4194-5. Epub 2019 Jan 31.
  14. Velazquez DM, Reidy KJ, Sharma M, Kim M, Vega M, Havranek T, Velazquez DM. The effect of hemodynamically significant patent ductus arteriosus on acute kidney injury and systemic hypertension in extremely low gestational age newborns. J Matern Fetal Neonatal Med. 2019;32(19):3209-3214. doi: 10.1080/14767058.2018.1460349.
  15. Capozzi G, Santoro G. Patent ductus arteriosus: patho-physiology, hemodynamic effects and clinical complications. J Matern Fetal Neonatal Med. 2011;24(1):6-15. doi: 10.3109/14767058.2011.607564.
  16. Winter RM, Wigglesworth JS. Unusual association of cerebral and renal abnormalities. Clin Dysmorphol. 1993;2(1):5-71.

Downloads

Published

2021-12-28

How to Cite

Borysova, T., Tverdokhlib, I., Obolonska, O., Korolenko, A., Diahovets, K., Surkov, D., & Usenko, T. (2021). Morphological characteristic of premature infants’s kidneys with opened Ductus Arteriosis (by the autopsy). Морфологія / Morphologia / Morfologìâ, 15(1), 28–38. https://doi.org/10.26641/1997-9665.2021.1.28-38

Issue

Vol. 15 No. 1 (2021)

Section

Статті

License

Copyright (c) 2021 Author, Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.