Chronic monocytic leukemia with transformation into acute monocytic leukemia. Clinical case

Authors

  • L. A. Pesotskaya SI «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine», Dnipro, Ukraine, Ukraine
  • A. S. Korolenko SI «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine», Dnipro, Ukraine, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2020.4.49-57

Keywords:

chronic myelomonocytic leukemia, dysplasia, acute monocytic leukemia

Abstract

Background. Chronic myelomonocytic leukemia (CML) is rarely diagnosed and it is 1 per 100 thousand adults annually, in the United States - in 4 per million people, which is about 1100 cases per year. This disease is more common for men over 60. Results. A clinical case of a rare long-term course of myelodysplastic chronic myelomonocytic leukemia (MDCMML) in a middle-aged woman with rapid transformation into acute monocytic leukemia (AMoL-M5v) with atypical fulminant course is presented. Changes in the blood test were identified accidentally during a routine examination. A retrospective analysis of the course of the patient's disease, anamnesis made it possible to draw attention to the severe course of vasculitis of unknown etiology, with a predominant lesion of the skin of the lower limbs, which required inpatient treatment (19 years ago); skin lesions in the form of transient erythema, spotty eruptions for more than 10 years, moderate cervical lymphadenopathy. According to the WHO criteria, the morphological data of the bone marrow puncture corresponded to the MD of the CML. The long course of the disease without an obvious clinical picture, neutrophil dysplasia, myeloid proliferation was atypical, which did not exclude the presence of previous oligomonocytic CML in the patient. A detailed picture of the disease appeared after a viral infection, bronchitis, antibiotic therapy. In the absence of an increase in the number of blasts in the bone marrow, in a few of them normal Auer's sticks were detected, which, according to the literature, is a rarity in CML and an unfavorable prognostic factor of rapid transformation into acute myeloid leukemia. Conclusion. Not typical for the course of acute monocytic leukemia in this case were the absence of significant blastemia and severe suppression of normal hematopoiesis with pronounced extramedular manifestations. There was febrile fever, hyperplasia of the gums, tonsils with ulcerative-necrotic changes in the oral mucosa, an increase in cervical lymph nodes in the form of packets up to 2 cm in diameter with signs of sarcomatous growth. Attention was drawn to the progression of skin lesions, which was prognostically unfavorable. Notable was the development of severe hemorrhagic syndrome without severe thrombocytopenia, significant changes in the coagulogram, as a manifestation of early severe coagulopathy. There was a spread of erythematous elements on the skin with itching, not controlled by antihistamines and corticosteroid drugs (maculopapular rashes of a pink-cyanotic color, in places of a confluent nature, small-point hemorrhages like vasculitis over the entire surface of the skin).

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Published

2021-09-25

How to Cite

Pesotskaya, L. A., & Korolenko, A. S. (2021). Chronic monocytic leukemia with transformation into acute monocytic leukemia. Clinical case. Морфологія / Morphologia / Morfologìâ, 14(4), 49–57. https://doi.org/10.26641/1997-9665.2020.4.49-57

Issue

Vol. 14 No. 4 (2020)

Section

Статті

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