Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations

Authors

DOI:

https://doi.org/10.26641/1997-9665.2020.3.65-69

Keywords:

prenatal period, spinal cord, malformations, macrometric parameters

Abstract

Background. A comprehensive integrated study of the human spinal cord in the prenatal period of ontogenesis will make it possible to deepen knowledge about the mechanisms of malformation and increase prognostic data, as well as the likelihood of their correction in utero in early gestation. Objective: to establish the characteristic signs of differences in the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis in comparison with fetuses with developmental anomalies. During the study, the following methods were used: anatomical, histological, immunohistochemical, morphometric and statistical. Results. All macrometric parameters of the spinal pulp in the studied malformations are lower than those of their age group. Thus, the parameters of the spinal cord of Siamese twins 17-18 weeks old corresponded to the parameters of fetuses of 14-15 weeks without malformations. In anencephals of 17-18 weeks, the total length corresponded to human fetuses of 11-12 weeks. At the same time, the length and diameter of the cervical and lumbosacral thickenings corresponded to similar parameters of human fetuses of 8-9 weeks. The length of the spinal cord of anencephals of 20-21 weeks actually corresponded to the length of the spinal cord of fetuses of 14-15 weeks, other parameters - 11-12 weeks. In fetuses with spina bifida 17-18 weeks, the length of the spinal cord was 14-15 weeks, the diameter of the thoracic part was 9-10 weeks, the diameter of the lumbosacral thickening was 8-9 weeks. In fetuses with spina bifida of 20-21 weeks, the length of the spinal cord also corresponded to 14-15 weeks, the length and diameter of the cervical and lumbosacral thickenings were similar to those of fetuses of 17-18 weeks. In fetuses with teratomas, the length of the spinal cord corresponded to fetuses of 14-15 weeks. Conclusion. Macrometric parameters of the spinal cord lesions of human fetuses with the above-described congenital anomalies lag behind in development compared with fetuses without malformations of the corresponding age period of ontogenesis. The exception is the fetus of a person with teratomas of 17-18 weeks, where, in addition to the length of the spinal cord, all other parameters correspond to their age group.

References

  1. Stepanenko AYu. [Dynamics of age-related changes in macroanatomic indices of cerebellum]. World of medicine and biology. 2011;2:47-9. Ukrainian.
  2. Bahney J, Von Bartheld C. The cellular composition and glia-neuron ratio in the spinal cord of a human and a non-human primate: comparison with other species and brain regions. Anat. Rec. 2018;301(4):697-710.
  3. Mavropulo TK, Bujalskiy OC, Ostromezka VM. [Ultrasound examination of spinal cord structures in premature infants]. Neonatology, surgery and perinatal medicine. 2011;1(1):50-2. Ukrainian.
  4. Shkolnikov VS, Tyholaz VO, Holod LP, Stelmaschuk PO, Halunko GM. [Structure of causes of late abortions and stillbirths in Vinnytsia region for 2010-2014]. Current issues of medical science and practice. 2015;82:211-220. Ukrainian.
  5. Stecenko TI. [Modern aspects of congenital anomalies of brain development]. Neuro News. 2008;1(6):17-25. Ukrainian.
  6. Yuskiv N. High rates of neural tube defects in Ukraine. Birth Defects Res. A Clin. Mol. Teratol. 2004;70(6):400-2.
  7. Maden M. Retinoids and spinal cord development. Journal of Neurobiology. 2005;10:726-738.
  8. De Onis M, Habicht J-P. Anthropometric reference data for international use: recommendations from a World Health Organization Expert Committee. Amer. J. Clin. Nutr. 1996;64(4):650-8.
  9. Volkov AE, Mihelson AF, Smirnova IV, Rymashevskiy AN. Cases of early ultrasound diagnostics of unseparated thoracopagus twins. Prenatal diagnostics. 2004;53(3):205-8.
  10. Glenn O, Barkovich A. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol. 2006;27(8):1604–11.
  11. Glenn O, Barkovich A. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 2. AJNR Am J Neuroradiol. 2006;27(9):1807-14.

Downloads

How to Cite

Prykhodko, S. O., & Shkolnikov, V. S. (2020). Comparative characteristics of the macrometric parameters of the human spinal cord in the prenatal period of ontogenesis with fetuses with malformations. Морфологія / Morphologia / Morfologìâ, 14(3), 65–69. https://doi.org/10.26641/1997-9665.2020.3.65-69

Issue

Vol. 14 No. 3 (2020)

Section

Статті

License

Copyright (c) 2020 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.