Stage of morphological changes in psoriatic arthritis.
DOI:
https://doi.org/10.26641/1997-9665.2020.1.16-22Keywords:
psoriatic arthritis, histomorphological studies, non-specific inflammatory process, dystrophic-degenerative processAbstract
Background. Chronically progressive course of psoriatic arthritis, not the certainty of pathogenetic units, and accordingly errors in diagnosis and treatment lead to significant negative results and disability of patients. Objective is to improve the results of the diagnosis of PA by examining the morphological features of the disease. Methods. Histomorphological studies performed on tissues removed during surgery on the joints in 32 patients. The material distributed into groups depending on the severity of the clinical manifestations of the disease. Results. At the beginning of the disease and at the exudative-proliferative stage, a pattern of pronounced inflammatory process, mainly exudative, serous-fibrinous character, was noted in the capsule of the joint. The most significant changes occurred in the synovial membrane, where marked proliferation of the integumentary synovial cells, hypertrophy and hyperplasia of the synovial membrane were observed with the formation of a large number of villi and folds. At histological examination in the tissues of the joint with a dystrophic-degenerative stage there was a pronounced exudative-proliferative inflammatory process, with significant degenerative-dystrophic and fibro-sclerotic changes. Conclusion. Histological studies in patients with PA, evidence of the presence of a sharp non-specific, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, syllabic history changes. Pathological changes in the articular cartilage and subordinate epiphysis bone are manifested by significant degenerative-dystrophic and destructive manifestations.References
- Burianov AA, Kvasha VP. Psoriaticheskiy artrit (voprosyi genezisa, diagnostika i lechenie) [Psoriatic arthritis (genesis, diagnosis and treatment)]. Kiev: Lenvyt; 2009. 234p. Russian.
- Ye H, Wang Y, Jenson AB, Yan J. Identification of inflammatory factor TNFα inhibitor from medicinal herbs. Exp Mol Pathol 2016;100(2):307–11.
- Gossec L, Smolen JS, Gaujoux-Viala C, et al. European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis. 2012;71(1):4–12.
- Acosta Felquer ML, Coates LC, Soriano ER Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review. J Rheumatol. 2014;41(11):2277–85.
- Baliwag J, Barnes DH, Johnston A. Cytokines in psoriasis. Cytokine. 2015;73(2):342–50.
- Diani M, Altomare G, Reali E. T cell responses in psoriasis and psoriatic arthritis. Autoimmun Rev. 2015;14(4):286–92.
- Wang MJ, Xu YY, Huang RY, Chen XM, Chen HM, Han L, Yan YH, Lu CJ. Role of an imbalanced miRNAsaxis in pathogenesis of psoriasis: Novel perspectives based on review of the literature. Oncotarget. 2017;8(3):5498–507
Downloads
How to Cite
Buryanov, A. A., Moroz, M. F., Kvasha, V. P., Kovalchuk, D. U., Dralov, Y. S., & Сhekushyn D. A. (2020). Stage of morphological changes in psoriatic arthritis. Морфологія / Morphologia / Morfologìâ, 14(1), 16–22. https://doi.org/10.26641/1997-9665.2020.1.16-22
Issue
Section
Статті
License
Copyright (c) 2020 Morphologia
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world.
The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.
