Features of vasculogenesis of the human prostate gland in the prenatal period of ontogenesis.
DOI:
https://doi.org/10.26641/1997-9665.2019.1.52-56Keywords:
prostate gland, vasculogenesis, immunohistochemical method, endothelial marker CD-34, prenatal ontogenesisAbstract
Background. As it is known today, the structural basis of the stroma of the prostate gland is formed by mesenchymal derivatives: connective tissue, microvasculature vessels, smooth muscle tissue. Scientists have identified patterns of formation of blood vessels in human fetuses, which are manifested by the unevenness of vasculogenesis and histogenesis and their unequal intensity in different regions of the prostate gland. In the peripheral regions of the prostate, blood vessels are formed earlier than in the central ones, due to which the prostatic units of the main glands differentiate more rapidly than the structures of the periurethral and transient zones of the prostate gland. An objective of the research: to identify of the immunohistochemical features of the formation of the regional bloodstream of the human prostate gland in the prenatal period of ontogenesis. Methods. 60 prostate glands of human aged of 12 to 36 weeks gestation, using immunohistochemical method by determining the CD 34 expression (1:50) (DAKO). Results. The analysis made it possible to establish that the predominant component of the stroma of the prostate in prenatal ontogenesis is a loose fibrous connective tissue that performs important morphogenetic functions. In the layers of connective tissue are numerous vessels. Capillaries are located more on the periphery of the organ. An intensive growth is observed, then a capillary plexus is formed. When reacting with the cytospecific marker of the endothelium CD-34 in the cytoplasm of the endothelial cells of the vascular prostate gland of a person aged 24-26 weeks, positive visualization of this marker is determined. Changes in the proliferative processes of the prostate were noted: the formation of the microvascular bed and glandular departments, the maturation of connective tissue. During this period, capillaries continue by separating from the previous microvessels. In particular, the growth of new capillaries parallel to the increase in the number of lymphoid formations. Obviously, microvascular neoplasms are more inherent in lymphoid structures, start to form and undergo differentiation. Growth buds arise on the basal surface of microvessels, mainly in those areas where pericytes and adventitious cells are located, in the same place the basal membrane is absent. Thus, the analysis of the features of the structure, morphological and histochemical differentiation of the vascular component of the prostate gland shows that vasculogenesis of the prostate is subject to a number of regularities. Conclusion. The formation and subsequent growth of the primary vascular modules of the prostate occurs at the interface of the connective tissue and prostatic epithelial cells. Integration connections on the territory of the vascular module are established with the help of connecting and main capillaries. The true capillary network develops on the basis of connecting and main capillaries. Pre- and postcapillaries arise first from the segments of the connecting and main capillaries, and then from the true capillaries. Zaporizhzhya state medical university.
References
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