On the question of classification of rat’s ovarian follicles.
DOI:
https://doi.org/10.26641/1997-9665.2018.4.116-121Keywords:
ovary, white rats, follicles, classification, progesteroneAbstract
Background. Ovaries, as part of the female reproductive system, play an important role in the normal and adequate functioning of the body. The reproductive systemare sensitive to the effects of environmental factors.Among frequent causes of defection in ovarian structure and functions are factors of different backgrounds, and above all - the effect of these factors on the formation of the reproductive system during pregnancy.After all, the fetal period is one of the critical periods of the morphosis.During the pregnancy period female sex hormones are widely used, in particular, progesterone - a hormone of the corpus luteum, which performs a number of important functions and is essential for the normal pregnancy course.So the consequences of intrauterine affection of progesterone on morphogenesis and fetal ovarian functioninghave not been sufficiently studied. One of the methods for the morphofunctional status of the ovaries assessment is to calculate and to determine the ratio of follicles at different stages of development.Most part of the publications considering the study of the structure of the follicles and their distribution occurred at the end of the twentieth century. As the basis of proposed classifications of follicles different parameters were taken - diameter of the follicle, the ratio of the diameter of the follicle to the number of follicular cells, the structure of the follicle.Objective. To determine the most convenient classification of rat ovarian follicles. Methods. Literature data was analyzed,including the International Histological nomenclature. Results. The classifications were characterizedand the conclusions were drawn about their practical significancefor studying the processes of folliculogenesis, especially after the action of various factors.Conclusion. The investigationof morphofunctional featuresof follicles according to various criteria helps to assess in more detail the changes in their structure and functioning and to identify possible pathological changes after the. various factors impact, in particular – hormones.References
- Boychuk AV, Nikitina IM, Sukharev AB, Kalashnikov NV, Babar TV. [Possibilities of the treatment of preterm labor of multiple pregnancy using sublingual forms of micronized progesterone]. Actual problems of pediatry, obstetrics and gynecology. 2018;1:41-7. Ukrainian. DOI 10.11603/24116-4944.2018.1.8625
- Grekova SP, Vodjanyk MO, Chernyshov VP. [The effect of progesterone and estradiol on the effect of costimulation of proliferation by proinflammatory cytokines]. Fiziologichnyj Zhurnal. 2002;48(4):63-9. Ukrainian
- Kolmakova Yu B, Uchakina RV, RyzhavskyBYa. [The effect of progesterone introduction of newborn rats in indices of brain, gonads and adrenal development]. Far East Medical Journal. 2010;1:94-8. Russian.
- Shkil NN, Sokolov MY, Smolyaninov YI, Belyaeva NY. [Studying the effect of ovarian stimulation in rats by the drugs Ovarinin and Folligon]. Siberian Herald of Agricultural Science. 2016;1:51-8. Russian.
- Zenkina VG, Karedina VS, Solodkova OA, Slutskaya TN, Yufereva AN. [Ovary morphology in androgenized rats when taking cucumaria-containing extract]. Pacific medical journal. 2007;4:70-2. Russian.
- Bessalova YeYu. [Physiologic and structural methods of evaluating the morphofunctional status of the ovaries of mammals]. Clinical anatomy and operative surgery. 2006;5(3):85-90. Russian.
- Lutsik AD, Ivanova AY, Kabak KS, Chaikovskyi YuB et al. [Histologiya lyudyny]. Kyiv: Knygaplus; 2003. 592 p. Ukranian.
- Lutsik AD, Chaikovskyi YuB et al. [Histologichna terminologiya. Mizhnarodna terminologiya z cytologiyi ta histologiyi lyudyny]. Kyiv: Medytsyna; 2010. 304 p. Ukranian.
- Pedersen T, Peters H. Proposal for a classification of oocytes and follicles in the mouse ovary. J ReprodFertil. 1968;17:555-7. PMID: 5715685
- Hirshfield AN, De Santi AM. Patterns of ovarian cell proliferation in rats during the embryonic period and the first three weeks postpartum. Biol Reprod. 1995;53(5): 1208-21. PMID:8527527
- Kezele P, Skinner MK. Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assembly. Endocrinology. 2003;144(8):3329-37.
- Mazaud S, Guyot R, Guigon CJ, Coudouel N, Le Magueresse-Battistoni B, Magre S. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Dev Biol. 2005;277(2):403-16. DOI:10.1016/j.ydbio.2004.10.001
- Picut CA, Dixon D, Simons ML, Stump DG, Parker GA, Remick AK. Postnatal ovary development in the rat: morphologic study and correlation of morphology to neuroendocrine parameters. Toxicol Pathol. 2015;43(3):343-53. DOI: 10.1177/0192623314544380.
- Yoshida M, Sanbuissyo A, Hisada S, Takahashi M, Ohno Y, Nishikawa A. Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection. J Toxicol Sci. 2009;34(1):189 – 97. PMID: 19265285.
- Hirshfield AN, Midgley AR. Morphological analysis of follicular development in the rat. Biology of reproduction. 1978;19:597-605.
- Cheng-kang X, Yun-he Zh. Apoptosis of rat’s ovarian follicle cells induced by triptolide in vivo. African Journal of Pharmacy and Pharmacology. 2010;4(6):422-30.
- Gaytán F, Morales C, Bellido C, Aguilar E and Sanchez-Criado JE. Proliferative activity in the different ovarian compartments in cycling rats estimated by the 5-bromodeoxyuridine technique. Biol Reprod. 1996;54:1356-65.
- Duggal PS, Van Der Hoek KH, Milner CR, Ryan NK, Armstrong DT, Magoffin DA, Norman RJ. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology. 2000;141(6):1971–6. DOI: 10.1210/endo.141.6.7509
- Osman P. Rate and course of atresia during follicular development in the adult cyclic rat. J Reprod Fertil. 1985;73(1):261-70. PMID: 4038517
- Takagi K, Yamada T, Miki Y, Umegaki T, Nishimura M, Sasaki J. Histological observation of the development of follicles and follicular atresia in immature rat ovaries. Acta Med Okayama. 2007;61(5):283–9. DOI: 10.18926/AMO/32892
- Bernal AB, Vickers MH, Hampton MB, Poynton RA, Sloboda DM. Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoSOne. 2010;5(12):e15558. DOI: 10.1371/journal.pone.0015558.
- Dixon D, Alison R, Bach U, Colman K, Foley GL, Harleman JH, Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, Van Esch E, Westwood FR, Vidal J, Yoshida M. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. J Toxicol Pathol. 2014;27(3-4):1S-107S. DOI: 0.1293/tox.27.1S.
- Hryhorieva OA, Kovalchuk KS. [Features of the ovarian internal structure of the offspring of rats after the progesterone administration during pregnancy]. Bulletin of scientific research. 2018;2:125-8. Ukrainian. DOI 10.11603/2415-8798.2018.2.9001
Downloads
How to Cite
Hryhorieva, O. A., & Kovalchuk, K. S. (2018). On the question of classification of rat’s ovarian follicles. Морфологія / Morphologia / Morfologìâ, 12(4), 116–121. https://doi.org/10.26641/1997-9665.2018.4.116-121
Issue
Section
Статті
License
Copyright (c) 2018 Hryhorieva O.A., Kovalchuk K.S., Morphologia

This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world.
The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.
