Mathematical model for predicting the risk of progression of cervical dysplasia associated with papillomavirus infection in women with infertility.

Authors

  • E. O. Kindrativ SHEI «Ivano-Frankivsk National Medical University», Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2018.4.41-47

Keywords:

prognostication, cervical intraepithelial neoplasia, infection of papillomavirus, infertility

Abstract

Background. During recent decades there has been a new concept of the pathogenesis of cervical cancer, according to which dysplasia of the cervix (CIN) of CIN1 is an inflammatory process with the development of pathological regeneration that corresponds to productive papillomavirus infection and, more often, may be reversible. Morphological manifestations of moderate to severe dysplasia of the cervix are discussed in the context of neoplasia. Objective. The determination of the predictor factors and create a mathematical model for predicting the risk of progression of cervical dysplasia associated with papillomavirus infection in women with infertility. Methods. The construction of the mathematical model, regression analysis, and the values of the coefficients of multiple regression were determined using the SPSS program. Results. To determine the risk of HPVI-associated CIN progression the mathematical model was created: RP CINI=0,011*Ki-67-0,011* NKSSE/CBD +0,009*p63+0,018*age+0,032*infertility form-0,075*infertility type-0,014*duration of infertility+1,481 (constant), where, Кі-67 –the level of expression of the marker of cell proliferation, %; р63 –the level of expression of the protooncogene, %; NKSSE/CBD – height index of non-keratinized stratified squamous epithelium (NKSSE) to a capillaries bulk density (CBD); an age: number of years of the patient; infertility form: 1 – hormonal, 2 – pipe, 3 – peritoneal, 4 – combined; infertility type: 1 – primary, 2 – secondary; a duration of infertility: number of years. Individual value RP CIN is interpreted according to the differential values of the split points: [0; 1,5] – low risk of progression; [1,5; 2,5], risk of moderate CIN progression; [2,5; 3] – risk of severe CIN progression. Conclusion. The proposed program and algorithm of mathematical modeling allows us to verify the degree of severity, to calculate the digital level of progression of CIN associated with PVI in women with infertility, to form groups of clinical supervision, to choose the strategy of adequate medical tactics and to timely apply preventive methods against the progress of this disease.

References

  1. Meiqun J, Jing H, Dong H, Jiang J, Wang M, Wei B, et al. HLA–DP is the cervical cancer susceptibility loci among women infected by high–risk human papillomavirus: potential implication for triage of human papillomavirus–positive women. Tumor Biology. 2016;37(6):8019-8025. doi: 10.1007/s13277-015-4673-7.
  2. Serrano B, Sanjosé S, Tous S, Quiros B, Muñoz N, Bosch X, et al. Human papillomavirus genotype attribution for HPVs 6, 11, 16, 18, 31, 33, 45, 52 and 58 in female anogenital lesions. European Journal of Cancer. 2015;51(13):1732-1741. doi: 10.1016/j.ejca.2015.06.001.
  3. Danilova NV, Andreeva YuYu, Zavalishina LE, Kekeyeva TV, Mal’kov PV, Frank GA: [Tumors of the cervix uteri. Morphological diagnostics and genetics: manual for doctors]. Moscow: Practical medicine;2012. 116 p. Russian.
  4. Bode-Lesniewska B, Caduff R. News in der aktuell gültigen WHO-Klassifikation der HPV-assoziierten Zervix-Läsionen. Praxis (Bern 1994). 2017;106(6):305-310. doi: 10.1024/1661-8157/a002623.
  5. Reich O, Regauer S, Marth C, Schmidt D, Horn L, Dannecker C, et al. Precancerous Lesions of the ervix, Vulva and Vagina According to the 2014 WHO Classification of Tumors of the Female Genital Tract. Geburtshilfe Frauenheilkd. 2015;75(10):1018-1020. doi: 10.1055/s-0035-1558052.
  6. Souho T, Benlemlih M, Bennani B. Human papillomavirus infection and fertility alteration: a systematic review. PLoS ONE. 2015;10(5). doi: 10.1371/journal.pone.0126936.

Downloads

How to Cite

Kindrativ, E. O. (2018). Mathematical model for predicting the risk of progression of cervical dysplasia associated with papillomavirus infection in women with infertility. Морфологія / Morphologia / Morfologìâ, 12(4), 41–47. https://doi.org/10.26641/1997-9665.2018.4.41-47

Issue

Vol. 12 No. 4 (2018)

Section

Статті

License

Copyright (c) 2018 Kindrativ E.O., Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.