Differential diagnostics of mesenhymal tumors of uterine corpus founded on immunophenotypes of neoplasms.

Authors

  • I. S. Shponka Dnipropetrovsk State Medical Academy, Ukraine
  • A. S. Goncharova Dnipropetrovsk State Medical Academy, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2011.2.19-23

Keywords:

mesenhymal tumors of uterine corpus, immunohistochemical markers, differential diagnostics

Abstract

Morphological diagnostics of mesenhymal uterine neoplasms is complex due to polymorphism of benign and malignant processes. The purpose of our research was to devise the complex differential diagnostics criterions for foregoing tumors founded on expression's indexes of biological tissue's properties markers studying. We determined, that for smooth muscle tumors with unknown malignant potential diagnostics, it will be an expedient to use as main markers p53, Ki-67, ER, PGR and as auxiliary p21, bax, VEGF, TSP-1, CD34. For differential diagnosis of leiomyomas and endometrial stromal tumors it is neсessary to use СD10, desmin, α-SMA, h-caldesmon, Ki-67. For definition of atypia's level in the tumors of endometrial stroma, the most informative will be diagnostical panel from Ki-67, p53, ER, PGR, and cyclin D1. To solve the issue of histogenesis will help the complex consists of CD10, α-SMA, desmin, та h-caldesmon.

References

  1. An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual anti-bodies / E. Oliva, R. H. Young, M. B. Amin, P. B. Clement // Am. J. Surg. Pathol. – 2002. – Vol. 26, № 4. – P. 403-412.
  2. Leiser A. L. Apoptotic and cell cycle regulatory markers in uterine leiomyosarcoma / A. L. Leiser, S. E. Anderson, D. Nonaka // Gynecol. Oncol. – 2006. – Vol. 101, № 1. – P. 86-91.
  3. Baker P. Endometrial stromal tumours of the uterus: a practical approach us-ing conventional morphology and an-cillary techniques / P. Baker, E. Oliva // J. Clin. Pathol. – 2007. – Vol. 60. – P. 235–243.
  4. Blaustein A. Blaustein's pathology of the female genital tract / A. Blaustein, R.J. Kurman. – 5th ed. – New York: Springer, 2002. – 1391 p.
  5. D'Angelo E. Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system / E. D'Angelo, L. G. Spagnoli, J. Prat // Hum. Pathol. – 2009. – Vol. 40, № 11. – P. 1571-1585.

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How to Cite

Shponka, I. S., & Goncharova, A. S. (2011). Differential diagnostics of mesenhymal tumors of uterine corpus founded on immunophenotypes of neoplasms. Морфологія / Morphologia / Morfologìâ, 5(2), 19–23. https://doi.org/10.26641/1997-9665.2011.2.19-23

Issue

Vol. 5 No. 2 (2011)

Section

Статті

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Copyright (c) 2011 Shponka I.S., Goncharova A.S., Morphologia

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