Status of adrenals at influence exogenous RNA in the conditions of the experimental blastomogenesis.

Authors

  • I. S. Khripkov Dnipropetrovsk State Medical Academy, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2011.2.91-93

Keywords:

adrenal gland, exogenous RNA, transplanted tumor

Abstract

The experimental research has been supplied on 70 white rats - males in mass of 140-160 to whom under a skin the tumoral strain of a carcinoma of Guerin has been transplanted. The operation purpose was learning of influence exogenous homologous tumoral RNA on a morfo-functional status of adrenals at animals with tumor. Tumour growth causes a strain of compensator mechanisms of adrenals at cellular level and is accompanied by response from a microcirculatory channel. Introduction exogenous homologous tumoral RNA an animal locks development of reactive changes in a parenchima and an organ stroma.

References

  1. Митченко Н. А. Тормозящее влияние гомологичной РНК на рост спонтанных опухолей у мышей высокораковых линий А и СН3 / Н. А. Митченко // Пат. физиология. – 1971. – Т. 15. – С. 45.
  2. Роничевская Г. М. Влияние препаратов печеночной РНК и выделенных при их очистке примесей на развитие асцитной опухоли Эрлиха / Г. М. Роничевская // Вопросы онкологии. – 1972. – Т. 15. – С. 49.
  3. Смирнов А. В. О возможности использования экзогенных РНК для анализа сложных эффектов биологически активных веществ / А. В. Смирнов // Бюл. экспер. биол. и мед. – 1985. – Т. 100, № 7. – С. 81-83.
  4. Diamond D. J. Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodthyronine transcriptional rate and mRNA stability changes in pituitary tumor cell / D. J. Diamond, H. M. Goodman // L. Mol. – 1985. - №1. – Р. 41-62.
  5. Niu M. C. Ribonucleic acid-induced changes in mammalian cell / M. C. Niu, C. C. Cordova , L. C. Niu // Proc. Natl. Acad. Sci. – 1961. - Vol. 47. – P. 1689-1700.
  6. Oldham R. K. Biotherapy: the forth modality of cancer treatment / R. K. Oldham // J. Cell Physiol. -1986. - № 4. – P. 91-99.
  7. Wallace L. M. RNA Interference Improves Myopathic Phenotypes in Mice Overexpressing FSHD Region Gene 1 (FRG1) / L. M. Wallace, S. E. Garwick-Coppens, R. Tupler // Mol/ Ther. – 2011. – Vol. 5. – P. 118.
  8. Wang D. Inhibition of nonsense mediated RNA decay by the tumor microenvironment promotes tumorigenesis / D. Wang, J. Zavadil, L. Martin // Mol. Cell. Biol. – 2011. – Vol. 5. – P. 107-112.

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How to Cite

Khripkov, I. S. (2011). Status of adrenals at influence exogenous RNA in the conditions of the experimental blastomogenesis. Морфологія / Morphologia / Morfologìâ, 5(2), 91–93. https://doi.org/10.26641/1997-9665.2011.2.91-93

Issue

Vol. 5 No. 2 (2011)

Section

Статті

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Copyright (c) 2011 Khripkov I.S., Morphologia

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