Characteristic of the effects of melatonin and epithalon on the condition of in the neurosecretory nuclei of the hypothalamus in rats stressed by light.

Authors

  • R. E. Bulyk Bukovinsky State Medical University, Ukraine
  • V. P. Pishak Bukovinsky State Medical University, Ukraine
  • N. V. Chernyavska Bukovinsky State Medical University, Ukraine
  • U. V. Lomakina Bukovinsky State Medical University, Ukraine
  • V. G. Vysotskaya Bukovinsky State Medical University, Ukraine
  • O. I. Smetanuk Bukovinsky State Medical University, Ukraine
  • M. I. Krivchanskaya Bukovinsky State Medical University, Ukraine
  • V. L. Voloshin Bukovinsky State Medical University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2011.2.32-38

Keywords:

с-fos, paraventricular nuclei, stress, melatonin, epithalon

Abstract

It has been studied the influence of melatonin and synthetic bioregulator epithalon against a background of the stress-induced changes of gene “over early answer” (c-fos) activity in the medial microcellular subnuclei of the hypothalamic rat’s PVNs during different 24-hour period (day and night). Expression of gene product – protein C-Fos – in animals, which were hold under casual light regime, demonstrated distinct circadian rhythm.  Under influence of light stress the daily index of c-Fos contain in rat’s mdPVN was higher than at night. Under influence of constant light melatonin in dosage 0,5 mg/kg the concentration of  с-Fos protein approached to the  norm of the concentration this protein in subnuclei mdPVNs of hypothalamus at night. Manifest differences in daily aspect were not found during epithalon administration in dosage 0,5mkg/kg.

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How to Cite

Bulyk, R. E., Pishak, V. P., Chernyavska, N. V., Lomakina, U. V., Vysotskaya, V. G., Smetanuk, O. I., Krivchanskaya, M. I., & Voloshin, V. L. (2011). Characteristic of the effects of melatonin and epithalon on the condition of in the neurosecretory nuclei of the hypothalamus in rats stressed by light. Морфологія / Morphologia / Morfologìâ, 5(2), 32–38. https://doi.org/10.26641/1997-9665.2011.2.32-38

Issue

Vol. 5 No. 2 (2011)

Section

Статті

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Copyright (c) 2011 Bulyk R.E., Pishak V.P., Chernyavska N.V., Lomakina U.V., Vysotskaya V.G., Smetanuk O.I., Krivchanskaya M.I.,Voloshin V.L., Morphologia

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