Formation and transformation of glands and muscle tissue in the prostate of human fetuses.

Authors

  • I. A. Piatsko Vitebsk State Order Of Peoples’ Friendship Medical University, Belarus
  • A. K. Usovich Vitebsk State Order Of Peoples’ Friendship Medical University, Belarus

DOI:

https://doi.org/10.26641/1997-9665.2018.3.111-115

Keywords:

prostate, epithelium, muscle tissue, glands, apoptosis

Abstract

Background. At the present time in the literature there is conflicting information about the course of the processes of human prostate morphogenesis. A more thorough study of the processes of morphogenesis in the pathologically unchanged prostate can facilitate understanding of the occurrence of atypical forms of glands and muscle bundles. Objective. To study in the human prostate the formation and transformation of glands and muscle tissue. Materials and methods. A morphometric study was performed on 19 prostate fetuses from 14 to 40 weeks of intrauterine development. Results. It was established that the transformation of epithelial buds into glandular tubules is not accompanied by an increase in their area, since the formation of ta lumen occurs by apoptosis. The main stages of the transformation of epithelial strands into typical alveolar-tubular glands are traced. At this insignificant increase in the specific area of the glandular parenchyma in the organ, the transformation of the developing glands occurs mainly due to their canalization (the specific area of the gland enlarges increases 3.8 times - p <0.05). Conclusions. Transformation of prostate glands in the prenatal period occurs in a certain sequence: the formation of epithelial buds, their canalization by apoptosis with the formation of epithelial ducts and prostatic ducts and the formation of end pieces of prostate glands from these ducts. In prenatal periods, the structure and orientation of smooth muscle bundles around the glands can not provide evacuation of the contents of the prostate glands.

References

  1. Brossner C, Petritsch K, Fink K, Auprich M, Madersbacher S, Adlercreutz H., Rehak P, Petritsch P. Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases. Urology. 2004;64(4):707-11.
  2. Toftgard R. Two sides to cilia in cancer. Nature Medicine. 2009;15:994-6.
  3. Mao P, Nakao K, Angrist A. Human prostatic carcinoma: an electron microscope study. Cancer Research. 1966;26:955–73.
  4. Kumar VL, Dewan S. Alpha adrenergic blockers in the treatment of benign hyperplasia of the prostate. International Urology and Nephrology. 2000;32:67–71. PMID:11057776
  5. Timms BG, Hofkamp LE. Prostate development and growth in benign prostatic hyperplasia. Differentiation. 2011;82(4-5):173-83. doi.org/10.1016/j.diff.2011.08.002.
  6. Shapiro E. Embriologic development of the prostate. Insights into the etiology and treatment of benign prostatic hyperplasia. Urol Clin North Am. 1990;17(3):487-93.
  7. Ernst LM, Ruchelli ED, Huff DS, editors. Color Atlas of Fetal and Neonatal Histology. New York: Springer; 2011. 414 р. doi:10.1007/978-1-4614-0019-
  8. Lugin I. [Spesial characteristic tissual interactions in morphogenesis in organs with the heterogeneous origin of tissue components]. The world of medicine and biology. 2012;4(8):77-9. Russian.
  9. Kolesnikov LL, Shevlyuk NN, Erofeeva LM. [Terminologia Embriologica. International terms on human embryology with official list of Russian equivalents]. Moscow: GEOTAR-MEDIA; 2014. 417 p. Russian.
  10. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nature Methods. 2012;9:671-5.
  11. Mytsik AV. [Using the ImageJ program for automatic morphometry in histological studies]. Omsk Scientific Herald. 2011;2(100):187-9. Russian.
  12. Skibo YV, Abramova ZI. [Methods for the study of programmed cell death. Educational and methodological manual for masters at the rate of "Theory of apoptosis"]. Kazan: FGAOU VPO KFU; 2011. 61 p. Russian.
  13. Schoenwolf GC, Larsen WJ. Larsen’s Human Embryology. 4th. Philadelphia: Churchill Livingstone Elsevier; 2009. 712 p.
  14. Kellokumpu-Lehtinen P, Santti R, Pelliniemi LJ. Correlation of early cyto differentiation of the human fetal prostate and Leydig cells. Anatomical Record. 1980;196:263-73. PMID:7406220

Downloads

How to Cite

Piatsko, I. A., & Usovich, A. K. (2018). Formation and transformation of glands and muscle tissue in the prostate of human fetuses. Морфологія / Morphologia / Morfologìâ, 12(3), 111–115. https://doi.org/10.26641/1997-9665.2018.3.111-115

Issue

Vol. 12 No. 3 (2018)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.