Depression and pain: some issues of comorbidity and treatment (Review).

Authors

  • V. I. Mamchur Дніпропетровська державна медична академія, Ukraine
  • O. V. Khomyak Дніпропетровська державна медична академія, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2011.3.24-34

Keywords:

antidepressants, pain, depression treatment, mediator systems, analgesics

Abstract

The article highlights the current understanding of the mechanisms of pain and depression comorbidity, especially - functioning of neurochemical systems in the brain and the anatomical and functional relationships of structures in the CNS of these pathological conditions. It shows the current classification of antidepressants, analyze the neurochemical aspects of their actions, effects on cognitive brain function and behavioral reactions to the formation of the sensations of pain, generalize mechanisms of action in the treatment of chronic pain. In the analysis of the literature it is concluded that depression and pain therapy impede each other, having common mechanisms of development, the leading points of contact they are changing the functioning of catecholaminergic neurotransmitter systems of the brain, the levels of certain cytokines, as well as the state of NMDA-dependent mechanisms of the brain. The question of their use for treatment of acute pain, including differentiated into non-opioid analgesics combined with, is not sufficiently understood.

References

  1. Алексеев В. В. Принципы лечения болевых синдромов / В. В. Алексеев // Трудный пациент. – 2006. – №12 [ Электронный ресурс]. – Режим доступа: http://www.t-pacient.ru/archive/tp12-2006/tp12-2006_240.html
  2. Применение антидепрессантов с различным механизмом действия при хронической ежедневной головной боли / А. В. Амелин, С. В. Тарасова, Ю. Д. Игнатов [и др.] // Журнал неврологии и психиатрии им. С. С. Корсакова. – 2007. – Т. 107, N 9. – С. 38-44.
  3. Вознесенская Т. Г. Хроническая боль и антидепрессанты / Т. Г. Вознесенская // Современные подходы к терапии. Актуальные вопросы лечения болевых синдромов в неврологии: XV Российский национальный конгресс «Человек и лекарство»: тезисы доклада. – Москва, 2008 [ Электронный ресурс]. – Режим доступа: http://paininfo.ru/ events/drug2008/1509.html
  4. Вознесенская Т. Г. Хроническая боль и депрессия / Т. Г. Вознесенская, А. М. Вейн // Сonsilium medicum. - 2000. - № 1 [Электронный ресурс]. – Режим доступа: http://old.consilium-medicum.com/media/psycho/n01/05.shtml
  5. Вознесенская Т. Г. Хроническая боль и депрессия / Т.Г. Вознесенская // Фарматека. – 2008. – Т. 6, № 10 [Электронный ресурс]. – Режим доступа: www.pharmateca.ru/magazines/ source/2008/06/pdf/ft160_is10.pdf
  6. Воробьева О. В. Депрессия в пожилом возрасте / О. В. Воробьева // Consilium Medicum. - 2007. – Т. 9, № 12 [Электронный ресурс]. – Режим доступа: http: // www.consilium-medicum. com/article/6451
  7. Селективные ингибиторы обратного захвата серотонина: современное положение в терапии депрессий / Л. А. Громов, Л. А. Чайка, О. Н. Гомон [та ін.] // Здоров’я України. – 2008. – № 3 [ Електронний ресурс]. – Режим доступу: http://rpt.health-ua.com/article/129.html
  8. Зиньковская Л. Я. Отсутствие антидепрессантоподобной активности лигандов полиамин-связывающих участков NMDA-рецепторов на моделях депрессии / Л. Я. Зиньковская, Ю. В. Кидин, И. В. Комисаров // Экспериментальная и клиническая фармакология. – 2006. –Т. 69, №1. – С. 3-4.
  9. Изнак А. Ф. Нейрональная пластичность как один из аспектов патогенеза и терапии аффективных расстройств / А. Ф. Изнак // Consilium medicum. Психиатрия и психофармакотерапия. - 2005. – Т. 7, № 1, – С. 24-27.
  10. Компендиум-2010 — лекарственные препараты / Под ред. В.Н. Коваленко, А. П. Викторова. – К. : Морион, 2010. - 2270 с.
  11. Кудрявцева Н. Н. Экспериментальная модель депрессии: нейрохимические изменения, эффекты имипрамина и циталопрама / Н. Н. Кудрявцева, И. В. Бакштановская, И. А. Мадорская [и др.] // Журнал невропатологии и психиатрии им. СС Корсакова. – 1992. – Т. 2, № 1. – С. 106-109.
  12. Левада О. А. Нейробиология депрессии: серотониновая система мозга / О. А. Левада // НевроNews. – 2008. – № 36 [ Электронный ресурс]. – Режим доступа: http://neuro.health-ua.com/article/70.html
  13. Левин Я. Венлафаксин (велафакс) в терапии хронических болей в спине / Я. Левин // Врач. – 2007. – № 10. - С. 62-66.
  14. Мосолов С. Н. Применение современных антидепрессантов в терапии депрессий / С. Н. Мосолов // Психиатрия и психофармакотерапия. – 2000. – Т. 1, № 1 [Электронный ресурс]. – Режим доступа: http://old.consilium-medicum.com/ media/psycho/00_01p/4.shtml
  15. Погосова Г. В. Современные подходы к лечению расстройств депрессивного спектра в общемедицинской практике / Г. В. Погосова // РМЖ. – 2007. – Т. 15, № 6. – С. 17-24.
  16. Саркисова К. Ю. Депрессивно-подобные особенности поведения у крыс линии wagrij и их коррекция при помощи антидепрессанта имипрамина / К. Ю. Саркисова // Cтресс и поведение: VII Междисциплинарная конференция по биологической психиатрии, 2003 [ Электронный ресурс]. – Режим доступа: mosmedclinic.ru/ conf_library/2003/4/389
  17. Смулевич А. Б. Депрессии в общей медицине / Смулевич А. Б. – М. : МИА, 2007. – 256 с.
  18. Ушкалова А. В. Современные антидепрессанты: проблемы рационального выбора / А. В. Ушкалова // Фарматека. Спецвыпуск: Психиатрия, Неврология. – 2006. – № 2 [ Электронный ресурс]. – Режим доступа: http:// www.pharmateca.ru/cgi-bin/statyi.pl?sid= 1487&mid=1085056570&magid
  19. A single dose of citalopram increases fear recognition in healthy subjects / M. Browning, C. Reid , P. J. Cowen [et al.] // J Psychopharmacol. – 2007. – Vol. 21, № 7. – Р. 684-690.
  20. Acute citalopram administration may disrupt contextual information processing in healthy males / S. Almeida, D. C. Glahn, S. V. Argyropoulos [et al.] // Eur. Psychiatry. – 2010. – Vol. 25, № 2. – P. 87-91.
  21. Antinociceptive effect of amitriptyline in mice of acute pain models / J. Indian, Paudel K.R., Das B.P. [et al.] // Exp. Biol. – 2007. – Vol. 45, № 6. – P. 529-531.
  22. Assessing anxiolytic-like effects of selective serotonin reuptake inhibitors and serotonin-noradrenaline reuptake inhibitors using the elevated plus maze in mice / T. Takeuchi, T. Owa, T. Nishino [et al.] // Methods Find. Exp. Clin. Pharmacol. – 2010. – Vol. 32, № 2. – Р. 113-121.
  23. Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain / I. A. Strigo, A. N. Simmons, S. C. Matthews [et al.] // Arch. Gen. Psychiatry. – 2008 . – Vol. 65, № 11. – Р. 1275-1284.
  24. Briley M. Clinical experience with dual action antidepressants in different chronic pain syndromes / M. Briley // Hum. Psychopharmacol. – 2004. – Vol. 19, № 1. – Р. 21-25.
  25. Briley M. Preclinical pharmacology of milnacipran / M. Briley, J. F. Prost, C. Moret // Int. Clin. Psychopharmacol. – 1996. – Vol. 11, № 4. – Р. 9-14.
  26. Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats / L. Bardin , S. Gregoire, M. Aliaga [et al.] // Neurosc. Res. – 2010. – Vol. 66, № 2. – Р. 135-140.
  27. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test / O. F. O'Leary, A. J. Bechtholt, J. J. Crowley [et al.] // Psychopharmacology (Berl). – 2007. – Vol. 192, № 3. – Р. 357-371.
  28. Depression and pain / M. J. Robinson, S. E. Edwards, S. Iyengar [et al.] // Front Biosci. – 2009. – Vol. 14. - Р. 5031-5051.
  29. Depression in rheumatoid arthritis: a systematic review of the literature with meta-analysis / C. Dickens, L. McGowan, D. Clark-Carter [et al.] // Psychosom. Med. – 2002. – Vol. 64, № 1. – Р. 52-60.
  30. Differential effects of acute and repeated citalopram in mouse models of anxiety and depression / C. Mombereau, T. L. Gur, J. Onksen [et al.] // Int. J. Neuropsychopharmacol. – 2010. – Vol. 13, № 3. – Р. 321-334.
  31. Differential effects of escitalopram on attention: a placebo-controlled, double-blind cross-over study / B. Drueke , J. Baetz, M. Boecker [et al.] //Psychopharmacology (Berl). – 2009. – Vol. 207, № 2. – Р. 213-223.
  32. Effect of co-administration of a serotonin-noradrenaline reuptake inhibitor and a dopamine agonist on extracellular monoamine concentrations in rats / Y. Kitaichi, T. Inoue, T. Izumi [et al.] // Eur. J. Pharmacol. – 2008. – Vol. 584, № 2-3. – Р. 285-290.
  33. Effect of escitalopram on the processing of emotional faces / W. C. Alves-Neto, V. G. Guapo, F. G. Graeff [et al.] // Braz. J. Med. Biol. Res. – 2010. – Vol. 43, № 3. – Р. 285-289.
  34. Effects of acute and chronic reboxetine treatment on stress-induced monoamine efflux in the rat frontal cortex / M. E. Page, I. Lucki // Neuropsychopharmacology. – 2002. – Vol. 27, № 2. – Р. 237-247.
  35. Effects of chronic administration of olanzapine, amitriptyline, haloperidol or sodium valproate in naive and anhedonic rats / M. Orsetti, L. Colella, A. Dellarole [et al.] // J. Psychopharmacol. – 2006. – Vol. 20, № 6. – Р. 782-788.
  36. Effects of milnacipran in animal models of anxiety and memory / V. K. Moojen, M. R. Martins, A. Reinke [et al.] // J. Neurochem. Res. – 2006. – Vol. 31, № 4. – Р. 571-577.
  37. Fatigue in patients with ankylosing spondylitis: relationships with disease-specific variables, depression, and sleep disturbance / R. Günaydin, A. Göksel Karatepe, N. Ceşmeli [et al.] // Clin Rheumatol. – 2009. – Vol. 28, № 9. – Р. 1045-1051.
  38. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression / L. Cervo, A. Canetta, E. Calcagno [et al.] // J. Neuroscience. – 2005. – Vol. 25, № 36. – P. 65-72.
  39. Hayashi T. Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways / T. Hayashi, M. Miyata, T. Nagata // Pharmacol. Biochem. Behav. – 2009. – Vol. 91, № 3. – P.441-446.
  40. Howren M. B. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis / M. B. Howren, D. M. Lamkin, J. Suls // Psychosom. Med. – 2009. – Vol. 71, №2. – P. 171-186.
  41. Invernizzi R. W. Role of TPH-2 in brain function: news from behavioral and pharmacologic studies / R. W. Invernizzi // J Neuroscience Researches. – 2007. – V. 85, № 14. – P. 303-305.
  42. Juś A. Modification of fentanyl analgesia by antidepressants / A. Juś, M. Bujalska, H. E. Makulska-Nowak // Pharmacology. – 2010. – Vol. 85, № 1. – Р. 48-53.
  43. Kerr J. S. The effects of reboxetine and amitriptyline, with and without alcohol on cognitive function and psychomotor performanc / J. S. Kerr, J. Powell, I. Hindmarch // Indian J. Exp. Biol. – 1996. – Vol. 34, № 5. – Р. 431-435.
  44. Kreiss D. S. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo / D. S. Kreiss, I. Lucki // J. Pharmacol. Exp. Ther. – 1995. – Vol. 274, № 2. – Р. 866-876.
  45. Kroenke K. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews / K. Kroenke, E. E. Krebs, M. J. Bair // Gen Hosp Psychiatry. – 2009. – Vol. 31, № 3. - Р. 206-219.
  46. Kumar S. Influence of antidepressant drugs on learning and memory paradigms in mice / S. Kumar, S. K. Kulkarni // Indian J. Exp. Biol. – 1996. – Vol. 34, № 5. – Р. 431-435.
  47. Lopez A. D. The global burden of disease / A. D. Lopez, C. C. Murrey // Nature medicine. – 1998. - №4. – P. 1241-1243.
  48. Miller A. H. Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression / A. H. Miller, V. Maletic, C. L. Raison // Biol. Psychiatry. – 2009. – Vol. 65, № 9. – Р. 732–741.
  49. Milnacipran (ixel) in the treatment of anxiodepressive and sexual disorders in patients with noninflammatory syndrome of chronic pelvic pain / G.V. Selitskiĭ, A. D. Kaprin, S. B. Izvozchikov [et al.] // Ter. Arkh. – 2007. – Vol. 79, № 5. – Р. 81-84.
  50. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats / H. Obata, M. Kimura, K. Nakajima [et al.] // J. Pharmacol. Exp. Ther. – 2010. – Vol. 334, № 3. – Р. 1059-1065.
  51. Overexpression of IL-1beta by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behavior / S. J. Campbell, R. M. Deacon, Y. Jiang [et al.] // Neurobiol. Dis. – 2007. – Vol. 27. – Р. 151-163.
  52. Pain associated with specific anxiety and depressive disorders in a nationally representative population sample / K. Beesdo, F. Jacobi, J. Hoyer [et al.] // Soc. Psychiatry Psychiatr. Epidemiol. – 2010. – Vol. 45, № 1. – Р. 89-104.
  53. Papakostas G. I. A meta-analysis of clinical trials comparing milnacipran, a serotonin - norepinephrine reuptake inhibitor, with a selective serotonin reuptake inhibitor for the treatment of major depressive disorder / G. I. Papakostas, M. Fava // Eur. Neuropsychopharmacol. – 2007. – Vol. 17, №1. – Р. 32 - 36.
  54. Pelissolo A. Depression and pain: prevalence and clinical implication / A. Pelissolo // Presse Med. – 2009 . – Vol. 38, № 3. – Р. 385-391.
  55. Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy / L. Sutcigil, C. Oktenli, U. Musabak [et al.] // Clinical and Developmental Immunology. – 2007. – Vol. 1. - Access mode: http://www.deepdyve.com/lp/ hindawi-publishing-corporation/pro-and-anti-inflammatory-cytokine-balance-in-major-depression-effect-7HHTa3jqJV
  56. Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy / L. Sutcigil, O. Cagatay, M. Ugur [et al.] // Clin. Dev. Immunol. – 2007. – Access mode: http://ukpmc.ac.uk/articles/PMC2248234/reload=0;jsessionid=9D5BF01DAD407BEB8EEB5EE053213 E5E
  57. Rénéric J. P. Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test / J. P. Rénéric, I. Lucki // Psychopharmacology (Berl). – 1998. – Vol. 136, №2. – P. 190-197.
  58. Rénéric J. P. In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed / J. P. Rénéric, M. Bouvard, L. Stinus // Eur. Neuropsychopharmacol. – 2002. – Vol. 12, № 2. – Р. 159-171.
  60. Rénéric J.P. In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs / J. P. Rénéric, M. Bouvard, L. Stinus // Behav. Brain. Res. – 2002. – Vol. 136, № 2. – Р. 521-532.
  61. Rivelli S. Depression and ischemic heart disease: what have we learned from clinical trials? / S. Rivelli, W. Jiang // Curr. Opin. Cardiol. – 2007. – Vol. 22. – Р. 286-291.
  62. Rogóz Z. Pharmacological profile of milnacipran, a new antidepressant, given acutely / Z. Rogóz, G. Skuza, J. Maj // Pol. J. Pharmacol. – 1999. – Vol.51, № 4. – Р. 317-322.
  63. Rummans T.A. Nonopioid agents for treatment of acute and subacute pain / T. A. Rummans // Mayo Clin. Proc. – 1994. – Vol.69, № 5. – Р. 481-490.
  64. Schreiber S. From selective to highly selective SSRIs: a comparison of the antinociceptive properties of fluoxetine, fluvoxamine, citalopram and escitalopram / S. Schreiber, C.G. Pick // Eur. Neuropsychopharmacol. – 2006. – Vol.16, № 6. – P. 464-468.
  65. Schwarz M. J. The role of substance P in depression / M. J. Schwarz, M. Ackenheil // Dialogues in clinical neuroscience. – 2002. – Vol. 4, № 1. – Р. 21-29.
  66. Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test / M. E. Page , M. J. Detke, A. Dalvi [et al.] // Psychopharmacology. – 1999. – Vol. 147, № 2. – Р. 162-167.
  67. Stahl S. M. Что болит при депрессии? (реферат) / S. M. Stahl // Сonsilium medicum. Обозрение психиатрии и медицинской психологии им. В. С. Бехтерева. – 2006. – Т. 3, №4 [ Электронный ресурс]. – Режим доступа: http://old.consilium-medicum.com/media/bechter/ 06_04/51.shtml
  68. Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin / S. Guzzetti, E. Calcagno, A. Canetta [et.al.] // European Journal of Pharmacology. – 2008. – Vol.10, № 594. – P.117-124.
  69. The antinociceptive properties of reboxetine in acute pain / S. Schreiber, R. Frishtick, I. Volis [et al.] // Eur. Neuropsychopharmacol. – 2009. – Vol. 19, № 10. – Р. 735-739.
  70. The effect of the NMDA receptor antagonist dizocilpine on behavioral manifestations of serotonin and adrenergic antidepressants in rats / K. Pruus, R. Rudissaar, L. Allikmets [et al.] // Methods Find. Exp.Clin. Pharmacol. – 2010. – Vol. 32, № 2. – Р. 123-128.
  71. The Indiana Cancer Pain and Depression (INCPAD) trial Design of a telecare management intervention for cancer-related symptoms and baseline characteristics of study participants / K. Kroenke, D. Theobald, K. Norton [et al.] // Gen. Hosp. Psychiatry. – 2009. – Vol. 31, № 3. – Р. 240-253.
  72. Tianeptine reduces morphine antinociceptive tolerance and physical dependence / C. C. Chu, J. P. Shieh, H. A. Shui [et al.] // Behav. Pharmacol. – 2010. – Vol. 21, № 5-6. – P. 523-529.
  73. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study / M. E. Lynch, A. J. Clark, J. Sawynok [et al.] // J.Pain. – 2005. – Vol. 6, № 10. – Р. 644-649.
  74. Treatment-related symptoms among underserved women with breast cancer: the impact of physician-patient communication / R. C. Maly, Y. Liu, B. Leake [et al.] // Breast Cancer Res. Treat. – 2010. – Vol. 119, № 3. – Р. 707-716.
  75. Tura B. The analgesic effect of tricyclic antidepressants / B. Tura, S. M. Tura // Brain Res. – 1990. – Vol. 518, № 1-2. – Р. 19-22.
  76. Wiech K. The influence of negative emotions on pain: Behavioral effects and neural mechanisms / K. Wiech, I. Tracey // Neuroimage. – 2009 . – Vol. 47, № 3. – Р. 987-994.
  77. Willis W. D. Role of neurotransmitters in sensitization of pain responses / W. D. Willis // Ann NY Acad. Sci. – 2001. – Vol. 933. – Р. 142-56.
  78. Yau J. L. Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats / J. L. Yau, J. Noble, C. Hibberd [et al.] // J. Neurosc. – 2002. – Vol. 22, № 4. - Р. 1436-1442.

Downloads

How to Cite

Mamchur, V. I., & Khomyak, O. V. (2011). Depression and pain: some issues of comorbidity and treatment (Review). Морфологія / Morphologia / Morfologìâ, 5(3), 24–34. https://doi.org/10.26641/1997-9665.2011.3.24-34

Issue

Vol. 5 No. 3 (2011)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.