Eritema-papulosis form rosacea – results of immunohistochemical research of the condition of the lesions.
DOI:
https://doi.org/10.26641/1997-9665.2011.4.60-66Keywords:
rosacea, the eritema-papulosis form, immunohistochemical researchesAbstract
Studying and the analysis of links pathogenesis of eritema-papulosis forms of rosacea by means of a wide spectrum of immunohistochemical markers became a research problem. For the decision of tasks in view by the author it is used a material of 12 diagnosed cases eritema-papulosis forms of rosacea at men at the age from 32 till 64 years. Use of immunohistochemical methods of research has allowed to reveal new links in pathogenesis rosacea and to establish a role of some cellular populations of a skin and cages of immune system in disease progressing. Besides, at use of the offered scheme of treatment dynamics of immunohistochemical indicators was observed considerably more expressed at eritema-papulosis forms. Treatment influence on an immune link was has been confirmed essential, concerning control, reduction of quantity CD4 + cages, and also changes in quantity CD1а +, CD138 + that CD68 + cages. Essential result the offered scheme gives in a direction of suppression of fibrous changes in derma and myofibroblastic transformations dendrocytes. Considerably the metabolism extracellular of matrix improves. Influence of treatment on a vascular component proves to be true reduction of density of vessels in parallel with decrease in expression VEGF.References
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Haritonova, E. G. (2011). Eritema-papulosis form rosacea – results of immunohistochemical research of the condition of the lesions. Морфологія / Morphologia / Morfologìâ, 5(4), 60–66. https://doi.org/10.26641/1997-9665.2011.4.60-66
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