Quantitative ultrastructural characteristics of platelets in the patients with diabetes mellitus type 2 in a compensation with arterial hypertension under correction of arterial blood pressure with losartan.
DOI:
https://doi.org/10.26641/1997-9665.2011.4.37-44Keywords:
diabetes mellitus type 2, compensation, arterial hypertension, platelets ultrastructure, losartanAbstract
We have conducted a quantitative evaluation of ultrastructural changes in the dynamics of platelets in the patients with diabetes mellitus type 2 in a compensation phase with arterial hypertension under correction of arterial blood pressure with losartan and with considering of microalbuminuria. It is shown that in the patients with normalbuminuria observed moderate degree violations of thrombocyte hemostasis, as a result of this is a significant increase in the relative amount of activated platelets with preservation of normal content aggregated and degranulated forms and the appearance of single platelets with an imbalance of alpha and delta granules.Losartan usage makes it possible to normalize ultrastructural disorders of platelets ranging from the 6th month of the treatment. In the patients with microalbuminuria showed a significant damage of thrombocyte hemostasis due to significant growth in the content of the activated, degranulated and aggregated forms of platelets and development of hyperactivation ofplateletsbyhyalinetype. The standard treatment for one year is accompanied by increasing imbalance of granulomer of most platelets and the degree of the heteromorphic pool with a significant increase in aggregate form. Inclusion of losartan in the treatment leads to a substantial reduction of pathomorphological changes of platelets, limitation of their hyperactivity and prevents the formation of giant spherical pseudopodial forms from the 6th month of starting treatment.
References
- Зимин Ю. В. Артериальная гипертония при сахарном диабете: особенности патогенеза и лечения (обзор) / Ю. В. Зимин // Тер. архив. – 1999. - № 10. – С. 15-20.
- Миронов А. А. Методы электронной микроскопии в биологии и медицине: Методическое руководство / А. А. Миронов, Я. Ю. Комиссарчик, В. А. Миронов. – СПб. : Наука, 1994. – 400 с.
- Полифункциональность тромбоцитов, их активация и возможности ее оценки / Л. И. Бурячковская, И. А. Учитель, А. Б. Сумароков [и др.] // Сердечно-сосудистые заболевания. Бюллетень НЦССХ им. А. Н. Бакулева РАМН. – 2007. – Т. 8, № 2. – С. 43-50.
- Coagulation and fibrinolytic system impairment in insulin dependent diabetes mellitus / F. Carmassi, M. Morale, R. Puccetti [et al.] // Thromb. Res. – 1992. – Vol. 67. – P. 643-654.
- Epstein M. Diabetes and hypertension: the bad companions / M. Epstein // J. of Hypertension. – 1997. – Vol. 15, Suppl. 2. – P. 55-62.
- Generation of trombin activity in relation to factor VIII: concentrations and vascular complications in type I (insulin-dependent) diabetes mellitus / S. H. Ibbotson, D. Wairnsley, J. A. Davis [et al.] // Diabetologia. – 1992. – Vol.35. – P. 863-867.
- Leukocyte-platelet aggregates as a marker of inflammation / L. Bouriachkovskaia, I. Uchitel, N. Dovlatova [et al.] // Platelets. – 2004. – Vol. 16, № 8. – P. 483-484.
- Platelet activation and biochemical markers of inflammation in patients with CHD and depression / L. Buriachkovskaia, E. Poliakova, A. Zorin [ et al.] // Atherosclerosis. – 2006. – Vol. 7, № 3. – P. 283-285.
- Sawatzke C. L. Fixation and embedding of small volumes of platelets for transmission electron microscopy / C. L. Sawatzke, C. C. Solomons // J. Clin. Pathol. – 1980. – Vol. 33, № 6. – P. 600-602.
- Weyrich A. Platelets: signaling cells in the immune continuum / A. Weyrich, G. Zimmerman // Trends in Immunology. – 2004. – Vol. 25, № 9. – P. 489-495.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2018 Morphologia
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world.
The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.
