Bone tissue reaction to some implants at experiment.

Authors

  • B. A. Magrupov Республиканский научный центр экстренной медицинской помощи МЗ Республики Узбекистан, Ташкент, Узбекистан, Uzbekistan
  • T. T. Shadmanov Республиканский научный центр экстренной медицинской помощи МЗ Республики Узбекистан, Ташкент, Узбекистан, Uzbekistan
  • A. A. Tashpulatov Республиканский научный центр экстренной медицинской помощи МЗ Республики Узбекистан, Ташкент, Узбекистан, Uzbekistan
  • R. R. Hodjaev Научно-исследовательский институт травматологии и ортопедии МЗ Республики Узбекистан, Ташкент, Узбекистан, Uzbekistan
  • E. Y. Valiev Республиканский научный центр экстренной медицинской помощи МЗ Республики Узбекистан, Ташкент, Узбекистан, Uzbekistan

DOI:

https://doi.org/10.26641/1997-9665.2012.2.19-28

Keywords:

reparative osteogenesis, white marble, allofibroblast culture

Abstract

Purpose. To analyze bone repair process in Wistar rats’ thigh, with the use of different biomaterials. Methods. Eighty male rats were used, and standard thigh bone cavities were created in each animal. The cavities were filled with: calcium carbonate, marble powder, allofibroblast culture and autogenous blood clot (control). The animals were euthanized 7, 14, 21, 30 and 60 days after surgery. The thigh bone amputated and submitted to a routine process for histological preparation: staining with Haematoxylin and Eosin (HE). Results. It was detected that all test materials promoted the formation of new bone; however the most marked activation of reparative osteogenesis was observed at implantation of marble powder and allofibroblast culture, less marked at calcium carbonate implantation. Conclusions. The marble and allofibroblast culture implants possess good biocompatibility and osteoinductivity and may serve as ideal material for repairing bone defects.

References

  1. Волова Т. Г. Биотехнология новых полимерных материалов: синтез, свойства, применение. Очерки экологической биофизики / Т. Г. Волова, Е. И. Шишацкая. – Новосибирск : Наука., 2003. – С. 106-119.
  2. Изучение общетоксического действия мраморной муки на экспериментальных животных / Т.Т. Шадманов, Б. А. Магрупов, Р. Р. Ходжаев, Х. У. Алиев // Фармацевт. журнал. – Ташкент. – 2010. - №1. – С. 63-67.
  3. Карлов А. В. Системы внешней фиксации и регуляторные механизмы оптимальной биомеханики / А. В. Карлов, В. П. Шахов. – Томск : STT, 2001. – 480 с.
  4. Поиск экспериментальной модели для изучения особенностей репаративного остеогенеза. Клинические и фундаментальные аспекты тканевой терапии / И. Г. Арсеньев, Г. А. Кесян, Р. З. Уразгильдеев [и др.] // Теория и практика клеточных биотехнологий : материалы Всероссийского симп. с междунар. участием. – Самара, 2004. – С. 17-18.
  5. Разработка и обоснование экспериментальной модели для изучения влияния различных костно-пластических материалов на остеогенез / И. Г. Арсеньев, Г. А. Кесян, Р. З. Уразгильдеев [и др.] // Актуальные вопросы клинической и экспериментальной медицины : науч.-практ. конф. мол. уч. : тезисы докл. – СПб., 2005. – С. 379-381.
  6. Федоров B. H. Влияние антиоксидантов на репаративную регенерацию костной ткани (экспериментальное исследование) : автореф. дис. канд. биол. наук / Федоров B. H. – М., 1991. – 18 с.
  7. Шишацкая Е. И. Биоактивные имплантаты на основе резорбируемых полиэфиров и гидроксиапатита для реконструктивного остеогенеза : материалы Междунар. биотехн. конгр. [«Bio-2007»]. Е. И. Шишацкая. – Москва, 2006. – С. 136.
  8. Lin C. External fixation with or without supplementary intramedullary Kirschner wires in the treatment of distal radial fractures / C. Lin, J. S. Sun, S. M. Hou // Can. J. Surg. – 2004. – Vol. 47, № 6. – P. 431-437.
  9. Mangano C. A new porous hydroxyapatite for promotion of bone regeneration in maxillary sinus augmentation: clinical and histologic study in humans / C. Mangano, E. G. Bartolucci, C. Mazzocco // Int. J. Oral Maxillofac. Implants. – 2003. – Vol. 18. – P. 23-30.
  10. Stimulatory effects of statins on bone marrow-derived mesenchymal stem cells. Study of a new therapeutic agent for fracture / M. Sonobe, K. Hattori, N. Tomita [et al.] // Biomed. Mater. Eng. – 2005. – Vol. 15, № 4. – P. 261-281.

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How to Cite

Magrupov, B. A., Shadmanov, T. T., Tashpulatov, A. A., Hodjaev, R. R., & Valiev, E. Y. (2012). Bone tissue reaction to some implants at experiment. Морфологія / Morphologia / Morfologìâ, 6(2), 19–28. https://doi.org/10.26641/1997-9665.2012.2.19-28

Issue

Vol. 6 No. 2 (2012)

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