Definition of morphological changes of hepar, myocardium and stomach cells in rats after carbamazepin and thyotriazolin administration.
DOI:
https://doi.org/10.26641/1997-9665.2012.3.37-42Keywords:
carbamazepin, thyotriazolin, hepar, myocardium, stomach, histological changesAbstract
We investigated the histological changes in rats after new complex drug administration. Seventy male white rats were used for this experiment. During 90 days they received carbamazepin and thyotriazolin compound. Compound were administered orally via gavage. We observed damaging action of high dose carbamazepin on hepar, myocardium and stomach. Our data suggest that thyotriazolin reduce toxic effect of carbamazepin on hepar, myocardium and stomach.References
- Влияние карбамазепина на содержание нейромедиаторных аминокислот и продуктов перекисного окисления липидов в структурах мозга крыс с аудиогенной эпилепсией / Г. Ю. Вицкова, Л. А. Маликова, Е. С. Косачева [и др.] // Нейрохимия. – 1998. – Т. 15, № 3. – С. 76-78.
- Крыжановский Г. Н. Общая теория патофизиологических механизмов неврологических и психопатологических синдромов / Г. Н. Крыжановский // Журн. неврол. и психиатр. – 2002. – Т. 102, № 3. – С. 4-8.
- Мамчур В. Й. Сучасний погляд на фармакологію протиепілептичних засобів / В. Й. Мамчур, В. І. Опришко, О. О. Нефьодов // Одеський медичний журнал. – 2006. – №1 (93). – С. 85-95.
- Модельные коразоловые судороги сопровождаются усилением генерации окиси азота и устраняются мексидолом и альфа-токоферолом / В. Г. Башкатова, Г. Ю. Вицкова, В. Б. Наркевич, В. Д. Микоян // Нейрофармакологияю – 2003. - №10. – С. 3-5.
- N-нитро-L-аргинин модулирует содержание оксида азота и процессы перекисного окисления липидов при модельных судорогах различной природы / Г. Ю. Вицкова, В. Г. Башкатова, В. Б. Наркевич [и др.] // Психофармакол. и биол. наркол. – 2002. – Т. 2, № 1-2. – С. 198-202.
- Опришко В. І. Пошук шляхів підвищення ефективності та безпеки протисудомних засобів / В. І. Опришко, К. О. Кравченко, В. Й. Мамчур // Вісник Вінницького національного медичного університету. – 2008. – №12 (2). – С. 332-334.
- Перспективный комбинированный противосудорожный препарат с нейропротективными свойствами на основе фиксированной комбинации тиотриазолина и карбамазепина / В. И. Опрышко, И. Ф. Беленичев, Л. И. Кучеренко [и др.] // Запорожский медицинский журнал. – 2009. – Т. 11, №5. – С. 117-121.
- Стефанов О. В. Доклінічні дослідження лікарських засобів: [методичні рекомендації] / О. В. Стефанов. – К. : Авіцена, 2002. – 527 с.
- Evaluation of carbamazepine pharmacokinetic profiles in mice with kainic acid - induced acute seizures / A. Nishimura, N. Honda, N. Sugioka N. [et al.] // Biol. Pharm. Bull. – 2008. – Vol. 31 (12). – Р. 2302-2308.
- Gamble C. L. Lamotrigine versus carbamazepine monotherapy for epilepsy / C. L. Gamble, P. R. Williamson, A. G. Marson // Cochrane Database Syst Rev. – 2006. – Vol. 25, №1. – Р. 744-752.
- Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy / L. Kaminow, J. R. Schimschock, A. E. Hammer [et al.] // Epilepsy Behav. – 2003. - Vol4, №6. – Р. 659-666.
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Opryshko, V. I., Skvyrska, K. O., Mamchur, V. I., Mazur, I. A., & Kucherenko, L. I. (2012). Definition of morphological changes of hepar, myocardium and stomach cells in rats after carbamazepin and thyotriazolin administration. Морфологія / Morphologia / Morfologìâ, 6(3), 37–42. https://doi.org/10.26641/1997-9665.2012.3.37-42
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