Heat Shock proteins expression in different types of classical Hodgkin`s Lymphoma.
DOI:
https://doi.org/10.26641/1997-9665.2013.1.78-81Keywords:
Hodgkin`s lymphoma, HRS-cells, heat shock proteinsAbstract
In the study estimation of heat shock proteins hsp60 and hsp90 expression in tumor tissue were conducted in lymphocyte rich, mixed cellularity and ymphocyte depleted (reticular type) variants of classical Hodgkins lymphoma. It was shown that HRS-cells and cellular microenvironment in the studied tumor tissues have in their cytoplasm heat shock proteins, what may cause resistance to inner and outer damage effects. Expression increases from lymphocyte rich to mixed cellularity and the most significant in tumor tissue of Hodgkin`s sarcoma.References
- Expression of Heat Shock Protein 60 in Normal and Neoplastic Human Lymphoid Tissues / Н. S. Jin, T. Yoshino, Z. Jin [et al.] // J. Clin. Exp. Hematopathol. – 2002. – Vol. 42, № 1. – Р. 26-32.
- Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity / B. Böll, F. Eltaib, K.S. Reiners [et al.] // Clin. Cancer Res. – 2009.– Vol. 15, № 16. – Р. 5108-16.
- HSP90 is essential for Jak-STAT signaling in classical Hodgkin Lymphoma cells / N. Schoof, F. von Bonin, L. Trümper, D. Kube // Cell Communication and Signaling. – 2009. – Vol. 7, № 17. – Р. 7-17.
- Hsu P.-L. Abundance of Heat Shock Proteins (hsp89, hsp60, and hsp27) in Malignant Cells of Hodgkin's Disease / P.-L. Hsu, S.-M. Hsu // Cancer Research. – 1998. – Vol. 58. – Р. 5507-5513.
- Key M. Immunohistochemical Staining Methods / M. Key. – Ojai, CA, USA : Bimedical Services, 2006. – 174 p.
- Soltys B. J. Mitochondrial-matrix proteins at unexpected locations: are they exported? / B. J. Soltys, R. S.Gupta // Trends Biochem. Sci. – 1999. – Vol. 24. – Р. 174-177.
- Survival in Hodgkin’s disease patients – report of 25 years of experience at the Milan Cancer Institute / G. Bonadonna, S. Viviani, V. Bonfante [et al.] // Eur. J. Cancer. – 2005. – Vol. 41. – P. 998-1006.
- The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties / S. J. Felts, B. A. Owen, P. Nguyen [et al.] // J. Biol. Chem. – 2000. – Vol. 275. – Р. 3305-3312.
- WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues / S. H. Swerdlow, E. Campo, N. L. Harris [et al.]. – Lyon: International Agency for Research on Cancer, 2008. – 439 p.
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Tumanskiy, V. O., & Shavrin, V. O. (2013). Heat Shock proteins expression in different types of classical Hodgkin`s Lymphoma. Морфологія / Morphologia / Morfologìâ, 7(1), 78–81. https://doi.org/10.26641/1997-9665.2013.1.78-81
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