Dynamics of erythrocyte surface cellular composition in patients with diabetes mellitus type 2 with arterial hypertension under correction of arterial blood pressure with losartan.

Authors

  • G. V. Dzyak ДЗ «Дніпропетровська медична академія МОЗ України», Ukraine
  • N. O. Pertseva ДЗ «Дніпропетровська медична академія МОЗ України», Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2013.1.31-38

Keywords:

diabetes mellitus type 2, arterial hypertension, erythrocyte cellular composition, reversibly and irreversibly transformation, losartan

Abstract

We have conducted a quantitative morphological evaluation of changes of erythrocyte surface cellular composition in patients with diabetes mellitus type 2 with arterial hypertension under correction of arterial blood pressure with losartan and with considering of glycaemic control level and microalbuminuria. It is shown that in the patients with diabetes mellitus in a compensation and subcompensation with arterial hypertension and microalbuminuria observedmoderate degree violations of erythrocyte surface cellular composition, as a result of this is a significant increase in the relative content of reversibly transformed cells.Insufficient glycaemic control in patients has been accompanied by considerable increase of reversible and irreversible transformed cells, especially in patients with microalbuminuria. The standard treatment for 1 year there has been a gradual increase in the degree of erythrocyte transformation. Inclusion of losartan in the treatment does not influence significantly the reversible transformation of erythrocytes, contributes to the normalization of the level of irreversibly transformed cells in patients with normalbuminuria and stabilizes them level with microalbuminuria, prevents the reduction of normal disk cells level.

References

  1. Витковский Ю. А. Патогенетическое значение лимфоцитарно-тромбоцитарной адгезии / Ю. А. Витковский, Б. И. Кузник, А. В. Солпов // Медицинская иммунология. – 2006. - № 5. – С. 745-752.
  2. Зубаиров Д. М. Молекулярные основы свертывания крови и тромбообразования / Д. М. Зубаиров. – Казань: Фэн, 2000. – 364 с.
  3. Козинец Г. И. Поверхностная цитоархитектоника клеток периферической крови в норме и при заболеваниях системы крови / Г. И. Козинец, Ю. А. Симоварт. – Таллин: Валгус, 1984. – 116 с.
  4. Методические подходы к исследованию реологических свойств крови при различных состояниях / И. Н. Медведев, А. П. Савченко, С. Ю. Завалишина [и др.] // Российский кардиологический журнал. – 2009. – №5. – С. 42–45.
  5. Молекулярные нарушения мембран эритроцитов и тромбоцитов при сосудистых осложнениях сахарного диабета типа 1 / Е. Б. Кравец, Н. В. Рязанцева, Н. М. Яковлева [и др.] // Бюллетень сибирской медицины. – 2006. - № 4. – С. 33-41.
  6. Реологические свойства и цитоархитектоника эритроцитов при нарушениях углеводного обмена / И. А. Романенко Т. С. Полятыкина О. А. Назарова [и др.] // Профилактика заболеваний и укрепление здоровья. – 2005. – № 4. – С. 45-48.
  7. Состояние эндотелиальной функции у подростков с ожирением / Е. И. Ройтман, О. М. Мирошниченко, М. П. Рубанова, С. В. Жмайлова // Матлы науч.-практич. конф., посвященной 15-летию клинических кафедр ИМО НовГУ, 27 июня 2009 г. – Новосибирск, 2009. – С.167-170.
  8. Токмакова А. Ю. Антикоагулянты в терапии диабетической макроангиопатии / А. Ю. Токмакова, Д. Н. Староверова, М. Б. Анциферов // Consilium Medicum. – 2002. – Т. 4, № 10. – С. 20-23.
  9. Mathewkutty S. Platelet perturbations in diabetes: implications for cardiovascular disease risk and treatment / S. Mathewkutty, D. K. McGuire // Expert. Rev. Cardiovasc. Ther. – 2009. – Vol. 7, № 5. – P. 541-549.
  10. Barkis G. L. Pathogenesis of hypertension in diabetes / G. L. Barkis // Diabetes Rev. – 1995. – Vol. 3. – P. 460-476.
  11. Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications / P. Martin-Gallan, A. Carrascosa, M. Gussinye, C. Dominguez // Free Rad. Biol. Med. – 2003. – Vol. 34, № 12. – P. 1563-1574.
  12. Heude B. Cognitive decline and fatty acid composition of erythrocyte membranes / B. Heude // Amer. J. Clin. Nutrition. – 2003. - Vol. 77, № 4. – P. 803-808.
  13. Sowers J. R. Role of insulin resistance and hyperinsulinemia in development of hypertension and atherosclerosis / J. R. Sowers, P. S. Sowers, J. D. Peuler // J. Lab. Clin. Med. – 1994. – Vol. 23. – P. 647-652.

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How to Cite

Dzyak, G. V., & Pertseva, N. O. (2013). Dynamics of erythrocyte surface cellular composition in patients with diabetes mellitus type 2 with arterial hypertension under correction of arterial blood pressure with losartan. Морфологія / Morphologia / Morfologìâ, 7(1), 31–38. https://doi.org/10.26641/1997-9665.2013.1.31-38

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Vol. 7 No. 1 (2013)

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