Experimental model for chondrodystrophy of large bones caused by an overdose of bisphosphonates.

Authors

  • S. O. Mostovoy ГУ Крымский государ-ственный медицинский университет имени С.И.Георгиевского, г. Симферополь, Ukraine
  • O. V. Ostapenko Национальный медицинский университет имени А.А.Богомольца, г. Киев, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2013.2.98-101

Keywords:

metaepifisate plate, pamired, chondrodystrophy

Abstract

The results of the influence of high doses of aminobifosfonate "Pamired" on condition of metaepifisate plates of long bones. The aim of investigation is to simulate and study the characteristics of lesions the morphostructure of organ with bisphosphonates. 48 laboratory rats at the age of 6 month were used during the investigation.The weight was about 120-150g. Femoral,humeral and tibial bones were studied with light microscopy.Degree of damage were studied with binocular microscope and photo nozzle "Canon" with enlargement 100, 800.Processes of calcification and dehydratation of cartilage caused by overdosing of remedy are shown. It lead to decrease in capacity of proliferation of chondrocytes, non-uniform width of growth plate and loss of zones.Qualitative variations at the microscopic level, which can be used as one of the models chondrodystrophy are shown.

References

  1. Ивановская Т. Е. Патологическая анатомия болезней плода и ребенка : [руководство] // Т. Е. Ивановская, Б. С. Гусман. - М. : Медицина, 1981. - Т. 2 -С. 56.
  2. Ковешников В. Г. / Скелетные ткани: хрящевая ткань, костная ткань // В. Г. Ковешников, М. Х. Абакаров, В. И. Лузин. – Луганск, 2000. - С. 69-72.
  3. Мороз В. А. Бисфосфонаты в современной клинической практике / В. А. Мороз, Л. Г. Ланько // Провизор. – 2009. – № 8. – С. 18-22.
  4. Науково-практичні рекомендації з утримання лабораторних тварин та роботи з ними / Ю. М. Кожем’якін, О. С. Хромов, М. А. Філоненко [та ін.] ; під ред. А. І. Соловьйова. - К. : Авіцена, 2002. - 155 с.
  5. Hauser P. Nephrin and endothelial injury/ P. Hauser, F. Collino, B. Bussolati // Curr. Opin. Nephron. Hypertens. - 2009. – Vol. 18. - P. 3-8.
  6. Matrix Metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones / M. T. Engsig, Q-J. Chen, T. H. Vu [et al.] // J.Cell Biol. - 2000. - Vol. 151, № 4. - P. 879-889.
  7. Pathologic classification of focal segmental glomerulosclerosis: a working proposal/ V. D. D’Agati, A. B. Fogo, J. A. Brujin [et al.] // Am. J. Kidney Dis. – 2004. – Vol. 43. – P. 368-382.

Downloads

How to Cite

Mostovoy, S. O., & Ostapenko, O. V. (2013). Experimental model for chondrodystrophy of large bones caused by an overdose of bisphosphonates. Морфологія / Morphologia / Morfologìâ, 7(2), 98–101. https://doi.org/10.26641/1997-9665.2013.2.98-101

Issue

Vol. 7 No. 2 (2013)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.