Features and patterns of expression of lectin receptors in the lungs of patients with chronic obstructive pulmonary disease exacerbation and remission.

Authors

  • L. S. Malofiy Івано-Франківський національний медичний університет, Івано-Франківськ, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2013.3.87-93

Keywords:

chronic obstructive pulmonary disease, segmental bronchi, lectins

Abstract

Background. Chronic obstructive pulmonary disease is a widespread pathology, and the problem of its diagnostics is still of current interest. Objective. To determine the principles of lectin receptors expression and distribution in patients with chronic obstructive pulmonary disease during remission and exacerbation. Methods. For lectinhistochemical investigations biopsy material from 54 patients with chronic obstructive pulmonary disease was used. All patients were subdivided into 2 groups: 25 at remission phase, 29 – at exacerbation. Direct lectinhistochemical method was used. Results. Wheat germ lectin (WGA) increases its affinity for squamous metaplasia; elderberry lectin and Snail lectin are reduced by epithelial cells while maintaining the reaction in areas of proliferation of bronchial epithelium in acute chronic obstructive pulmonary disease. Konkanavalin A lectin in most cases had weakly positive reaction on luminal surface of epithelial cells during remission of chronic obstructive pulmonary disease. Conclusion. The presence of wheat germ lectin and konkanavalin A in epitheliocytes of segmental bronchi reveals the formation of a chronic inflammation.

References

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How to Cite

Malofiy, L. S. (2013). Features and patterns of expression of lectin receptors in the lungs of patients with chronic obstructive pulmonary disease exacerbation and remission. Морфологія / Morphologia / Morfologìâ, 7(3), 87–93. https://doi.org/10.26641/1997-9665.2013.3.87-93

Issue

Vol. 7 No. 3 (2013)

Section

Статті

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