Interrelation between prooxidant-antioxidant status and destructive changes in the lungs of white rats with the later periods of an experimental pneumonia.

Authors

  • I. V. Chelpanova Львівський національний медичний університет імені Данила Галицького, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2013.4.86-90

Keywords:

prooxidant-antioxidant status, morphology, pneumonia, rat

Abstract

Background. Study of pathogenic mechanisms, early diagnosis and early treatment of acute pneumonia has acquired the special significance and is one of the approach in modern therapy, pulmonology and pathological physiology. Still unknown, is the interrelation between prooxidant-antioxidant status and destructive changes in the lung tissue in experimental pneumonia in it's later periods. Objective. To reveal the peculiarities between the processes of lipid peroxidation and antioxidant status and destruction of the lung tissue in experimental models of acute pneumonia. Methods. The study was conducted on 60 mature rats Wistar. The control group were 20 intact animals, and 40 rats were infected by Staphylococcus aureus, which caused an experimental model of acute pneumonia. Indicators of lipid peroxidation and antioxidant enzyme activity of lung tissue were determined in intact rats and in animals with experimental models of acute pneumonia on the fourth and tenth day after infection. Results. We found the increased rate of lipid peroxidation products on the fourth day after intranasal infection by Staphylococcus aureus, which caused an experimental model of acute pneumonia in rats. At the same time, in the lung tissue, the activity of SOD and catalase were decreased. Changes in the rate of superoxidedismutase / diene conjugates acquired in this period, the lowest value among all periods of the experiment of acute staphylococcal pneumonia. Conclusion. This is confirmed by increase in the value of the ratio of superoxidedismutase activity / diene conjugates content in the lung tissue. In lung tissue specimens ware absorved the regression of pneumonia foci. In these areas the alveoli were not fully straightened, the alveolar septum were thickened infiltrated by cell round infiltration. In specimens there are some areas of edema of the lung tissue.

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How to Cite

Chelpanova, I. V. (2013). Interrelation between prooxidant-antioxidant status and destructive changes in the lungs of white rats with the later periods of an experimental pneumonia. Морфологія / Morphologia / Morfologìâ, 7(4), 86–90. https://doi.org/10.26641/1997-9665.2013.4.86-90

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Vol. 7 No. 4 (2013)

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Статті

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