Pathological features of the central nervous system lesions with Epstein-Barr virus in patients with HIV/AIDS.

Authors

  • V. N. Kozko Харьковский национальный медицинский университет, Ukraine
  • A. V. Gavrylov Харьковский национальный медицинский университет, Ukraine
  • A. V. Bondarenko Харьковский национальный медицинский университет, Ukraine
  • V. V. Gargin Харьковский национальный медицинский университет, Ukraine
  • Y. V. Zots Харьковский национальный медицинский университет, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2013.4.37-41

Keywords:

brain, HIV, Epstein-Barr virus

Abstract

Background. HIV infection/AIDS is a social disease and morbidity in some segments of the population is threatening. One of the target organs for HIV is the nervous system. The central nervous system lesion occurring in the form of meningoencephalitison the background of HIV infection is one of the leading death causes in patients with severe immunosuppression. Objective. Reveal the typicalmorphologic changes in the central nervous system during Epstein-Barr virus meningoencephalitis in patients with HIV/AIDS. Methods. Brain tissue and meningesof deceased patients with Epstein-Barr virus meningoencephalitis. Selected 6 deaths – three women and three men, aged 28 to 34 years. Following routine procedure histologic sections were produced, which were stained with hematoxylin and eosin staining, Nissl. Results. We showed signs of development of subacute encephalitis with the presence of giant areas of demyelination by morphological study of the combination of clinical cases of HIV and Epstein-Barr virus infection. In brain tissue we identified giant cells. In addition to this significant feature of the combination of HIV and Epstein-Barr virus infection can be considered productive development of vasculitis with thrombosis and ischemic brain lesions. During histological studies in HIV-infected patients were found: infiltration of the vessel wall by leukocytes, edema and proliferative changes in the intima. All this leads to a narrowing of the lumen and thrombosis with further possible infarct, vessel rupture and hemorrhage. Conclusion. It is established that in case of damage of the central nervous system with Epstein-Barr virus in HIV patients develops subacute giant cell encephalitis with the presence of demyelination areas, a bland astrogliosis, development of productive vasculitis with thrombosis, that complicated by ischemic lesions of the brain.

References

  1. Національна оцінка ситуації з ВІЛ/СНІДу в Україні за 2012 р. / Український центр профілактики і боротьби зі СНІДом Міністерства охорони здоров’я України, Всесвітня організація охорони здоров’я (ВООЗ), Обєднана програма Організації Об’єднаних Націй з ВІЛ/СНІД, Міжнародний Альянс з ВІЛ/СНІД в Україні. – К., 2012. – 39 с.
  2. [National Assessment of HIV/AIDS in Ukraine by 2012 / Ukrainian Center for Prevention and Control of AIDS of the Ministry of Health of Ukraine, the World Health Organization (WHO), the United Nations Programme on HIV/AIDS International HIV/AIDS Alliance in Ukraine]. Кiev (Ukraine) 2012. 39 p. Ukrainian.
  3. Евтушенко С. К. НейроСПИД как одна из актуальных проблем современной практической неврологии / С. К. Евтушенко // Международный неврологический журнал. - 2006. – Т. 5, № 9. - С. 147-157.
  4. Yevtushenko SK. [NeuroAIDS as one of the urgent problems of modern neurology practice]. International neurological journal. 2006;5(9):147-57. Russian.
  5. Manfredi R. AIDS and other manifestations of HIV infection / R. Manfredi // JAMA. – 2005. – Vol. 293. – P. 1393-1394.
  6. Manfredi R. AIDS and other manifestations of HIV infection. JAMA. 2005;293:1393-4.
  7. Stevens L. HIV infections: the basics / L. Stevens, C. Lynm, R. Glass // JAMA. – 2006. – Vol. 296. – P. 892.
  8. Stevens L., Lynm C., Glass R. HIV infections: the basics. JAMA. 2006;296:892.
  9. Тимченко В. Н. Поражение нервной системы при ВИЧ-инфекции / В. Н. Тимченко // Детск. инф. - 2009. - Т. 8, № 1. - С. 32-35.
  10. ТimchenkoVN. [Nervous system damage in HIV infection]. Pediatricinfections. 2009;8(1):32-5. Russian.
  11. Яковлев Н. А. НейроСПИД: Неврологические расстройства при ВИЧ-инфекции, СПИДе / Н. А. Яковлев, Н. М. Жулев, Т. А. Слюсарь. - М. : МИА, 2005. - 278 с.
  12. Yakovlev NA, Zhulev NM, Slyusar TA, authors. [NeuroAIDS: Neurological disorders in HIV infection/AIDS]. Мoscow (Russia): МIА; 2005. 278 p. Russian.
  13. Особенности изменения гематоэнцефалического барьера ВИЧ-инфицированных больных с разными этиологическими возбудителями менингоэнцефалита / А. И. Гоженко, Н. А. Гуменюк, В. С. Гойдык [и др.] // Междунар. неврол. журн. – 2012. – Т. 4, № 50. – С. 29-32.
  14. Gozhenko AI, Gymenyk NA, Goydik VS, Burlachenko VP, Nasibulin BA. [Features of the blood-brain barrier changes of HIV-infected patients with different etiological agents of meningoencephalitis]. International neurological journal. 2012;4(50):29-32. Russian.
  15. Цинзерлинг В. А. Инфекционные поражения нервной системы. Вопросы этиологии, патогенеза и диагностики / В. А. Цинзерлинг, М. Л. Чухловина. – СПб. : ЭЛБИ. - 2011. - 592 с.
  16. Zinserling VA, Chukhlovin ML, authors. [Infections of the nervous system. The etiology, pathogenesis and diagnosis questions]. St. Peterburg (Russia): ELBI; 2011. 592 p. Russian.

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How to Cite

Kozko, V. N., Gavrylov, A. V., Bondarenko, A. V., Gargin, V. V., & Zots, Y. V. (2013). Pathological features of the central nervous system lesions with Epstein-Barr virus in patients with HIV/AIDS. Морфологія / Morphologia / Morfologìâ, 7(4), 37–41. https://doi.org/10.26641/1997-9665.2013.4.37-41

Issue

Vol. 7 No. 4 (2013)

Section

Статті

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