Microscopic and ultramicroscopic characteristic of heart valves in human.
DOI:
https://doi.org/10.26641/1997-9665.2014.3.67-71Keywords:
atria-ventricular valve, ventriculo-vascular valve, cusp, light microscopy, electron microscopyAbstract
Background. Valvular apparatus of the heart is the frequent object of the surgical operations for today. Morphological changes which are happed within valves of the heart at time of cardiac diseases the modern medicine considers on the clinical, instrumental, histological, cytological and ultramicroscopical levels. The cardiac surgeons that make the heart valve replacement using the tissue engineering have the great interest in front of the heart valves. The achievements of the modern medicine are impossible without the fundamental morphological investigations. Objective. To study the morphological features of the cusps of human heart valves on the light and ultramicroscopic levels. Methods. We have reviewed the structure of cusps of 48 heart valves of adults. It was used a light and electron microscopy which enabled us to study the morphology of cusps of atria-ventricular and ventriculo-vascular heart valves. Results. The data indicate that cusps of heart valves are stratified. Layers of cusps are made of different types of fibrous connective tissues. The spongy layer is made of loose connective tissue, the fibrous layer – dense regular connective tissue, ventricular layer – dense irregular connective tissue. The arrangement of these layers in the cusps of atria-ventricular heart valves (in the direction from atrium toward ventricle) is: spongy, fibrous and ventricular. The arrangement of these layers in the cusps of ventricular-vascular heart valves (in the direction from side that is faced to the wall of blood vessel toward the ventricle) is: fibrous, spongy, ventricular. Conclusion. The position of data layers within cusp of atria-ventricular valves differs from position of data layers within ventriculo-vascular valves. These changes of tissue localization correlate to haemodynamic conditions during heart cycle.
References
- Knishov GV. [Cardiosurgery in Ukraine: past, present, future]. Heart and vessels. 2003;1:8-14. Russian.
- Sokolov VV. [Comparative morphology of heart valves]. Rostov-na-Donu: Publishing house of Rostov state medical university; 2003. 250 p. Russian.
- Bilavka IV, Kravchenko IM, Zerbino DD. [Bicuspid aortic valve: clinical pathology]. Medicines of Ukraine. 2009;4(130):69-73. Ukrainian.
- Stepanchuk AP. [Morphological changes of the valvular apparatus of human heart in acquired valvular diseases]. Visnik morphologii. 2008;14(1):247-9. Ukrainian.
- Fedoniuk LYa, Zaharova VP, Krikunov OA. [Morphological characteristic of human heart valves in infective endocardities]. Bucovinian medical herald. 2004;8(4):83-5. Ukrainian.
- Orlovskii PI, Gritsenko VV, Uhnev AD, Evdokimov SV, Gavrilenkov VI; Shevchenko UiL. [Artificial heart valves]. OLMA Media Grupp; 2007. 448 p. Russian.
- Mendelson K, Schoen FJ. Heart valve tissue engineering: concepts, approaches, progress, and challenges. Annals of Biomedical Engineering. 2006;34(12):1799-819.
- Schmidt D, Mol A, Breymann Chr. Living autologous heart valves engineered from human prenatally harvested progenitors. Circulation. 2006; 114[suppl I]: P. I-125-I-131. http://www.circulationaha.org.
- Vesely I. Heart valve tissue engineering. Circ. Res. 2005;97:743-55. http://circres.ahajournals.org/content/97/8/743.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2018 Morphologia
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world.
The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.
