Subtypes of human atypical lymph nodes, defined based on comparative morphological analysis.

Authors

DOI:

https://doi.org/10.26641/1997-9665.2016.2.45-52

Keywords:

human lymph nodes, classification, hemal nodes, hemolymph nodes, hyperemic lymph nodes, erythrophagocytosis

Abstract

Background. Lots of articles describe structure of lymph nodes with blood in their sinuses, but there are still many controversies between them due to the absence of single system of classification. Objective. The purpose of this work was to characterize the structure of human atypical lymph nodes and offer the new system of their classification. Methods. Atypical lymph nodes were taken during autopsy from patients who died due to cardiovascular or respiratory pathology. Standard histological methods were used including staining with hematoxylin and eosin. Results. Based on comparative morphological study we subdivided all atypical lymph nodes into three subtypes. I - Hemolymph node – it receives mixture of blood and lymph; during filtration through the system of sinuses all erythrocytes are eliminated, while efferent lymph vessels receive pure lymph. Such nodes are usually revealed close to kidneys and spleen. II – Hemal nodes – they receive blood through direct communication between blood vessels and sinuses; depending on the type of afferent vessel they are further subdivided into arterial and venous. Their efferent vessels contain blood with comparatively high content of leukocytes. III – Hyperemic lymph node – there are no afferent vessels bringing blood to the sinuses, but there are lots of dilated blood vessels with signs of hemoconcentration. All atypical lymph nodes contain different number of extravasated erythrocytes, assuming the possibility to filtrate blood antigens. Conclusion. Analyzing different types of human lymph nodes we offer a new system of their classification; the major criteria are summarized in the article.

References

  1. Afanasiev YuI, Yurina NA, editors. [Histology, cytology and embryology: a textbook]. 5th ed., rev. and enl. Moscow: Meditsina; 2002. 744 p. Russian.
  2. Afanasiev YuI, Yurina NA, editors. [Histology, embryology, cytology]. 6th ed.. rev. and enl. Moscow: GEOTAR-Media; 2012. P. 93-101. Russian.
  3. Mescher AL. Junqueira's basic histology: text and atlas. 13th ed. McGraw-Hill Medical; 2013. 480 p.
  4. Ross MH, Pawlina W. Histology: a text and atlas: with correlated cell and molecular biology. 6th ed. Lippincott Williams & Wilkins; 2011. 974 p.
  5. Elmore SA. Histopathology of the lymph nodes. Toxicol Pathol. 2006; 34(5): 425–454. doi: 10.1080/01926230600964722.
  6. National Toxicology Program [Internet]. National Institute of Environmental Health Sciences. Nonneoplastic Lesion Atlas - Lymph Node - Congestion; [updated 2015 Jan 27]. Available from: http://ntp.niehs.nih.gov/nnl/immune/lymph_node/congest/index.htm
  7. Turner DR. The vascular tree of the haemal node in the rat. J Anat. 1969;104(Pt 3):481-93.
  8. Zhang W, Yasuda M, Hosaka YZ, Nasu T. Scanning electron microscopic study of the vascular system in the hemal node of the bovine cervical region. J Vet Med Sci. 2013 Jan 31;75(1):79-83.
  9. Zidan M, Pabst R. Histological, histochemical and immunohistochemical study of the haemal nodes of the dromedary camel. Anat Histol Embryol. 2004 Oct;33(5):284-9.
  10. Weller, CV. The hemolymph nodes. In: Downey VE, editor. Handbook of Hematology. Vol. 3. New York: Harber; 1938. P1759-87.
  11. Avtandilov GG. [Introduction to quantitative pathological morphology]. Moscow: Meditsina; 1980. 216 p. Russian
  12. Pototska OYu, Lapsar HS. [Peculiarities of human pancreatolienal hemolymph node structure and cellular composition]. Morphologia. 2016;10(1):77-86. Russian.
  13. Castenholz A, Castenholz HF. Casting methods of scanning electron microscopy applied to hemal lymph nodes in rats. Lymphology. 1996 Sep;29(3):95-105.
  14. Pellas TC, Weiss L. Deep splenic lymphatic vessels in the mouse: a route of splenic exit for recirculating lymphocytes. Am J Anat. 1990 Apr;187(4):347-54.
  15. Hogg CM, Reid O, Scothorne RJ. Studies on hemolymph nodes. III. Renal lymph as a major source of erythrocytes in the renal hemolymph node of rats. J Anat. 1982 Sep;135(Pt 2):291-9.
  16. Sasaki K. Erythrophagocytosis of the lymph node macrophages caused by autotransplantation of the splenic tissue into the lymph nodes of rat. Anat Anz. 1990;171(5):335-42.
  17. Jordan, HE. The significance of hemal nodes. J Morphol. 1927;44(1):89-115. DOI: 10.1002/jmor.1050440105
  18. Zhang W, Nasu T, Hosaka YZ, Yasuda M. Comparative studies on the distribution and population of immunocompetent cells in bovine hemal node, lymph node and spleen. J Vet Med Sci. 2012 Apr;74(4):405-11.
  19. Akaydin Bozkurt Y, Kabak M. Morphology of haemal nodes in the roe deer (Capreolus capreolus). Anat Histol Embryol. 2010 Oct;39(5):456-61. doi: 10.1111/j.1439-0264.2010.01016.x.
  20. Zidan M, Pabst R. Histology of hemal nodes of the water buffalo (Bos bubalus). Cell Tissue Res. 2010 Jun;340(3):491-6. doi: 10.1007/s00441-010-0962-z.
  21. Warthin AS. Normal histology of the human hemolymph glands. Am J Anat. 1901;(1):63-80.
  22. Turner DR. The reticulo-endothelial components of the haemal node. A light and electron microscopic study. J Anat. 1971;108(Pt 1):13-22.

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Pototskaya, O. Y., & Lapsar, H. S. (2016). Subtypes of human atypical lymph nodes, defined based on comparative morphological analysis. Морфологія / Morphologia / Morfologìâ, 10(2), 45–52. https://doi.org/10.26641/1997-9665.2016.2.45-52

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Vol. 10 No. 2 (2016)

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