Structure and individual anatomical variability of the I-III lobules of the human cerebellar hemispheres.

Authors

  • O. Yu. Stepanenko Kharkiv National Medical University, Ukraine
  • N. I. Maryenko Kharkiv National Medical University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.3.279-282

Keywords:

human, cerebellum, individual anatomical variability

Abstract

Background. Morphological changes of cerebellar lobules are found in many congenital and acquired diseases of the cerebellum. In recent years, thanks to modern imaging techniques morphological changes of the hemispheric and vermal lobules can be detected in vivo. However, criteria of imaging diagnostic methods which are based on information about normal structure of the cerebellum, do not take into account the features of individual anatomical variability, gender and age characteristics. Objective - to investigate individual variability and features of variant anatomy of the I-III lobules of the human cerebellar hemispheres. Methods. Research was conducted at the Kharkiv regional bureau of forensic medicine on 100 cerebellums of people of both sexes 20-99 years old who died of causes unrelated to brain pathology. During the forensic autopsy the cerebellum and brain stem were separated and fixed during one month in 10% formalin solution. Parasagittal sections of cerebellar hemispheres were investigated. Results. The shape of the I-III lobules of the human cerebellar hemispheres is quite varied. Differences of the structure of these lobules depend on the characteristics of the branching of the white matter, the number of secondary branches and cerebellar folia. We described 4 variants of the shape of the II-III lobules of the human cerebellar hemispheres; 3rd variant is the most common. That variant can be used as anatomical standard of the lobules. Conclusion. Described variants of the shape of the cerebellar lobules can be used as criteria standards in current imaging techniques for the diagnostics of various diseases of the CNS.

References

  1. Leonard JR. Ojemann JG. Dandy–Walker Syndrome. In: Youmans Neurological Surgery, 5th ed., vol. 3. WB Saunders; 2004. p. 3285–3288.
  2. Oakes WJ, Tubbs RS. Chapter 212, Chiari Malformations. In: Youmans Neurological Surgery, 5th ed., vol. 3. WB Saunders; 2004. p. 3347-3361.
  3. Baloh R, Yee R, Honrubia V. Late cortical cerebellar atrophy. Clinical and oculographic features. Brain. 1986 Feb;109 ( Pt 1):159-80.
  4. Courchesne E, Saitoh O, Townsend JP, Yeung-Courchesne R, Press GA, Lincoln AJ, Haas RH, Schriebman L. Cerebellar hypoplasia and hy-perplasia in infantile autism. Lancet. 1994 Jan 1;343(8888):63-4. doi:10.1016/S0140-6736(94)90923-7
  5. Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Vaituzis AC, Dickstein DP, Sarfatti SE, Vauss YC, Snell JW, Lange N, Kaysen D, Krain AL, Ritchie GF, Rajapakse JC, Rapoport JL. Quanti-tative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 1996 Jul;53(7):607-16.
  6. Seidman LJ, Biederman J, Liang L, Valera EM, Monuteaux MC, Brown A, Kaiser J, Spencer T, Faraone SV, Makris N. Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometry. Biol Psychiatry. 2011 May 1;69(9):857-66. doi: 10.1016/j.biopsych.2010.09.053.
  7. Stoodley CJ. Distinct regions of the cerebellum show gray matter decreases in autism, ADHD, and developmental dyslexia. Front Syst Neurosci. 2014 May 20;8:92. doi: 10.3389/fnsys.2014.00092.
  8. Anderson CM, Rabi K, Lukas SE, Teicher MH. Cerebellar lingula size and experiential risk factors associated with high levels of alcohol and drug use in young adults. Cerebellum. 2010 Jun;9(2):198-209. doi: 10.1007/s12311-009-0141-5.
  9. DelBello MP, Strakowski SM, Zimmerman ME, Hawkins JM, Sax KW. MRI analysis of the cerebellum in bipolar disorder: a pilot study. Neuropsychopharmacology. 1999 Jul;21(1):63-8.
  10. Larsell O, Jansen J. The comparative anatomy and histology of the cerebellum. The human cerebellum, cerebellar connections, and the cerebel-lar cortex. Minneapolis: University of Minnesota Press; 1972. 268 p.
  11. Stepanenko OYu, Maryenko NI. [Features of the individual anatomical variability of I-III branches of white matter of the human cerebellum]. Current issues in pharmacy and medicine: science and practice. 2015;(2):140-6. Russian.

How to Cite

Stepanenko, O. Y., & Maryenko, N. I. (2016). Structure and individual anatomical variability of the I-III lobules of the human cerebellar hemispheres. Морфологія / Morphologia / Morfologìâ, 10(3), 279–282. https://doi.org/10.26641/1997-9665.2016.3.279-282

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