Features of treatment pathomorphosis in the skin of psoriatic patients undergoing narrowband UV-B therapy (311nm).

Authors

  • E. A. Dyadyk P.L.Shupik National Medical Academy of Post-Graduate Education, Kyiv, Ukraine
  • I. O. Zhdanova
  • K. V. Romanenko Mariupol Cenral city hospital, Ukraine
  • L. G. Nekrasova Bogomolets National Medical University, Kyiv, Ukraine
  • O. O. Borovaya

DOI:

https://doi.org/10.26641/1997-9665.2016.3.150-156

Keywords:

psoriasis, narrowband UV-B therapy, Ki-67, filaggrin, CD4 -lymphocytes, СD8 -lymphocytes

Abstract

Background. Psoriasis is one of the most widespread chronic inflammatory dermatosis, affecting from 2 to 7% of population. Objective. The assessment of morphological peculiarities of treatment pathomorphosis in patients with psoriasis at using UV-therapy. Method. Skin samples for histological studies and investigation of Ki-67 and filaggrin expression in epidermis were obtained from 14 patients with vulgar psoriasis before and after narrowband UV-B therapy (311nm). Results. Prior to therapy, epidermis exhibited signs of acanthosis, papillomatosis, hyperkeratosis, parakeratosis, Munro microabscess and lymphocytic exocytosis; stratum granulosum was either present in the form of small islets or absent. Derma underwent perivascular histiolymphocytic infiltration and contained dilated vessel. The number of Ki-67+ cells in psoriatic foci was 5 times more numerous as in the skin of healthy volunteers (p<0,001). The course of narrowband UV-B therapy resulted in epidermal thinning, hyperkeratosis and parakeratosis, restoration of the stratum granulosum, decrease of epidermal exocytosis and inflammatory infiltrates in the derma. Narrowband UV-B therapy had led to a 66% decrease of Ki-67-positive keratinocytes (p<0.002). Conclusions. Taken together these data allows to consider CD4/CD8 0,60-0,62 ratio as objective efficacy indicator and immunohistochemical threshold for evaluation treatment adequacy. It is concluded that narrowband UVB-therapy (311nm) have beneficial effect on histological skin changes, proliferative activity and differentiation of keratinocytes.

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How to Cite

Dyadyk, E. A., Zhdanova, I. O., Romanenko, K. V., Nekrasova, L. G., & Borovaya, O. O. (2016). Features of treatment pathomorphosis in the skin of psoriatic patients undergoing narrowband UV-B therapy (311nm). Морфологія / Morphologia / Morfologìâ, 10(3), 150–156. https://doi.org/10.26641/1997-9665.2016.3.150-156

Issue

Vol. 10 No. 3 (2016)

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