Investigation of pure magnesium alloy behavior in-vitro in simulated body solutions.

Authors

  • E. V. Husak Sumy State University Institute of Applied Physics, National Academy of Sciences of Ukraine, Ukraine
  • O. V. Solodovnik Sumy State University, Ukraine
  • O. M. Mischenko Zaporizhzhia State Medical University, Ukraine
  • А. A. Yanovska Sumy State University Institute of Applied Physics, National Academy of Sciences of Ukraine, Ukraine
  • O. S. Iarmolenko Sumy State University, Ukraine
  • V. O. Kurganska Sumy State University, Ukraine
  • K. A. Diedkova Sumy State University, Ukraine
  • M. V. Pogorielov Sumy State University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.3.110-113

Keywords:

Mg alloy, implants, biodegradation, corrosion resistance, mechanical properties, simulated body solutions

Abstract

Background. Pure magnesium and its alloys are promising biodegradable biomaterials for cardiovascular stents and orthopedic implants due to their outstanding biocompatibility, biomechanical compatibility and osteoinduction. But the fabrication of a biodegradable Mg-based implant and its corrosion control are still in the initial stage. Objective. Our aim was to evaluate the corrosion properties of pure Magnesium alloy in-vivo. Methods. The corrosion properties of magnesium were assessed using in vitro corrosion method in bulk with simulated body solutions (SBF). Six screws were immersed into SBF solution with a pH value of 7.4 at 37oC for 42 days. The pH value and the samples mass were recorded during the immersion every 14 days, with replacement a new solution. Results. Three degradation periods were indicated during the experiment. Primary period is characterized by quick loss of mass up to 18,94% ,and sharp pH increase from 7.4 to 9.8 due to raising of OH-concentration caused by the release of Mg2+. During the first immersion period we can see the formation of oxide layer on the screw surface. At the next immersion the indicator's value of pH was 9,3 and the weight loss was less – 5,57%. At the final immersion the oxide layer was disrupted. This is evidenced by the frequency of reducing implant mass on 58% and increasing pH values to 9.54. Conclusion. Pure Mg alloys are characterized by the fast degradation that restricts their application as orthopedic materials. To optimize Mg alloy degradation alloying elements such as Ca, Zr, Zn and Mn should be used.

References

  1. Witte F. The history of biodegradable magnesium implants: A review. Acta Biomaterialia. 2010;(6):1680-92.
  2. Agarwal S, Curtin J, Duffy B, Jaiswal S. Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibil-ity and surface modifications. Materials Science and Engineering. 2016;68(1):948–9639. doi: 10.1016/j.msec.2016.06.020
  3. Chaya A, Yoshizawa S, Verdelis K, Myers N, Costello BJ, Chou DT, Pal S, Maiti S, Kumta PN, Sfeir C. In vivo study of magnesium plate and screw degradation and bone fracture healing. Acta Biomater. 2015 May;18:262-9. doi: 10.1016/j.actbio.2015.02.010.
  4. Zhang E, Yin D, Xu L, Yang L, Yang K. Microstructure, mechanical and corrosion properties and biocompatibility of Mg–Zn–Mn alloys for biomedical application. Mater Sci Eng. 2009;29:987-93.
  5. Kraus T, Fischerauer SF, Hänzi AC, Uggowitzer PJ, Löffler JF, Weinberg AM. Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone. Acta Biomater. 2012 Mar;8(3):1230-8. doi: 10.1016/j.actbio.2011.11.008.
  6. Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006 Mar;27(9):1728-34.
  7. Zeng R, Dietzel W, Witte F, Hort N, Blawert C. Progress and challenge for magnesium alloys as biomaterials. Adv Eng Mater. 2008;10(8):B3-B14. DOI: 10.1002/adem.200800035.
  8. Song YW, Shan DY, Han EH. Electrodeposition of hydroxyapatite coating on AZ91D magnesium alloy for biomaterial applica-tion. Materials Letters. 2008;62(9):3276-9.
  9. Yu K, Chen L, Zhao J, Li S, Dai Y, Huang Q, Yu Z. In vitro corrosion behavior and In vivo biodegradation of biomedical β-Ca3(PO4)2/Mg–Zn composites. Acta Biomater. 2012 Jul;8(7):2845-55. doi: 10.1016/j.actbio.2012.04.009.
  10. Sun Y, Zhang B, Wang Y, Geng L, Jiao X. Preparation and characterization of a new biomedical Mg–Zn–Ca alloy. Mate. Des. 2012;34:58–64.
  11. Hornberger H, Virtanen S, Boccaccini AR. Biomedical coatings on magnesium alloys - a review. Acta Biomater. 2012 Jul;8(7):2442-55. doi: 10.1016/j.actbio.2012.04.012.
  12. Youwen Y, Ping W, Qiyuan W, Hong W, Yong L, Youwen D, Yuanzhuo Z and Cijun S.The enhancement of Mg corrosion resistance by alloying Mn and laser-melting. Materials. 2016;9(216):1-10.
  13. Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, Windhagen H. In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials. 2005 Jun;26(17):3557-63.
  14. Kokubo T, Miyaji F, Kim HM. Spontane-ous formation of bonelike apatite layer on chemically treated titanium metals. J Am Ceram Soc. 1996;79:1127-9.
  15. Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic. J Biomed Mater Res. 1990 Jun;24(6):721-34.
  16. Xin Y. Corrosion behavior of biomedical AZ91 magnesium alloy in simulated body fluids. J Mater Res. 2007;22(7):2004-11.
  17. Xin Y, Huo K, Tao H, Tang G, Chu PK. Influence of aggressive ions on the degradation behavior of biomedical magnesium alloy in physiological environment. Acta Biomater. 2008 Nov;4(6):2008-15. doi: 10.1016/j.actbio.2008.05.014.

Downloads

How to Cite

Husak, E. V., Solodovnik, O. V., Mischenko, O. M., Yanovska А. A., Iarmolenko, O. S., Kurganska, V. O., Diedkova, K. A., & Pogorielov, M. V. (2016). Investigation of pure magnesium alloy behavior in-vitro in simulated body solutions. Морфологія / Morphologia / Morfologìâ, 10(3), 110–113. https://doi.org/10.26641/1997-9665.2016.3.110-113

Issue

Vol. 10 No. 3 (2016)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.