The features of structural remodeling of rat testicles at poststrumectomic hypothyroidism.

Authors

  • I. Ye. Нerasуmyuk I. Horbachevsky Ternopil State Medical University, Ukraine
  • O. P. Ilkiv I. Horbachevsky Ternopil State Medical University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.3.94-98

Keywords:

strumectomy, arteries, veins, edema, sclerosis

Abstract

Introduction. The lack of thyroid hormones leads to the decrease in basal metabolism and violation of the functional state of different organs and systems. One of the leading places is occupied by the cardiovascular disorders which affect the state of gonads. Objective - to determine the nature of morphofunctional reorganization of rat testicles and features of their bloodstream remodeling after the strumectomy. Methods. The experiments were conducted on mature white male rats which underwent the strumectomy. The material for histology were taken after 1, 3, 7, 14 and 28 days after the surgery. Histological sections stained with hematoxylin and eosin, by Van Ghison method. Results. In 1 day after the strumectomy the arterial and venous plethora was observed, which was combined with stromal edema. 3 days after the surgical intervention the morphological signs of organ circulatory disorders were partially reduced. However, the stromal edema remained and was accompanied by reduce in number of cell layers in spermatogenic epithelium with the increasing of intervals between them and their detachment from the basement membrane. In seven days morphological manifestations of vascular responses became more obvious. One could observe the narrowing of the orifices of side branches of the small arteries from the trunks. Identified changes progressed up to 14 days. Arteries with particularly thick walls and narrowed lumen were often detected. In tubules the signs of fibrous transformation were detected. On the 28th day of experiment the signs of disorders of blood circulation and nourishment of testicles were further compounded. Seminiferous tubules looked devastated. Their fibrous transformation was observed with the growth of connective tissue in the interchannel intervals. Conclusion. After the strumectomy in the rat testicles it was observed the significant circulatory disorders of organ leading to the degenerative changes in the stroma and parenchyma. The progression of degenerative changes leads to the reduction of spermatogenic epithelium, fibrous transformation of seminiferous tubules with the growth of connective tissue in the interstices.

References

  1. Kazakov AV, Kravchun NA, Ilyina IM, et al. [Reference Dictionary for Endocrinologist]. Kharkov: SAM; 2009. 682 p. Russian.
  2. Efіmova AS, editor. [Endocrinology]. Kyiv: Vyshcha Shkola; 2004. 494 p. Ukrainian.
  3. Shved MІ, Pasechko NV, Martynyuk LP, et al. Clinical endocrinology in schemes and tables. Ternopil: Ukrmedknyha; 2006. 344 p. Ukrainian.
  4. Bodnar PM, editor: [Endocrinology]. Vinnytsya: Nova Knyha; 2010. 464 p. Ukrainian.
  5. Platonova NM, Sviridonova MA, Troshina EA. [Thyroid dysfunction and the hemostatic system]. Ter Arkh. 2014;86(10):92-6. Russian.
  6. Krassas GE, Pontikides N. Male reproductive function in relation with thyroid alterations. Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):183-95.
  7. Spivak ZhS. [The state of the reproductive system in men with infertility and subclinical hypothyroidism]. International medical journal. 2012;(4):94-6. Russian.
  8. Spivak JS, Bondarenko VA [Cholesterol levels in the blood and functional state of testes in infertile men, patients with primary hypothyroidism]. Problemi Endokrinnoi Patologii. 2015;(1):53-8 p. Russian.
  9. Wajner SM, Wagner MS, Maia AL. Clinical implications of altered thyroid status in male testicular function. Arq Bras Endocrinol Metabol. 2009 Nov;53(8):976-82.
  10. Shormanov IS. [Vascular renal system in the pulmonary trunk stenosis with different levels of circulation compensation]. Biull Eksp Biol Med. 2004;137(3):332-5. Russian.
  11. Shormanov SV, Kulikov SV. [Morphological changes in liver blood vessels in the modeling of the pulmonary trunk stenosis and after its removing]. Biull Eksp Biol Med. 2007;144(9):342-5. Russian.
  12. Esipova IK, Kaufmann AI, Kryuchkova GS, Shahlamov VA, Yarovaya IM. [Essays on hemodynamic restructuring of the vascular wall]. Moscow: Medicine; 1971. 311 p. Russian.

Downloads

How to Cite

Нerasуmyuk I. Y., & Ilkiv, O. P. (2016). The features of structural remodeling of rat testicles at poststrumectomic hypothyroidism. Морфологія / Morphologia / Morfologìâ, 10(3), 94–98. https://doi.org/10.26641/1997-9665.2016.3.94-98

Issue

Vol. 10 No. 3 (2016)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.