Morphological features of the globose nucleus of the cerebellum

Authors

  • D. N. Shyian Kharkov National Medical University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.1.92-95

Keywords:

morphology, globose nucleus, the cerebellum

Abstract

Background. The study of the clinical anatomy and functional features of the cortex, subcortical and conductive pathways of the cerebellum is necessary for clinicians for elaboration of rational surgical approaches to these formations, for determination the localization of pathological processes associated with these formations. In this article morphological features of the globose nucleus of the cerebellum were studied. Objective. The aim of this study is to investigate the morphological features of spherical nuclei of the cerebellum. Methods. The study was conducted at 340 specimens of the cerebellum of people aged from 20 to 99 years old. Macro- and microscopic, morphometric, histologic methods and methods of statistical analysis were used. Results. Individual variability in size of spherical nucleus considering the size of the cerebellar vermis was established. It determines the location of the border relatively to the median sagittal plane, topographic and anatomic particular location in relation to other nuclei of the cerebellum. Variantions of the nucleus were established. Conclusion. We have established dimensions of globose nucleus, its shape and location regarding the median-sagittal plane. The globose nucleus on the sections made in a horizontal plane has a bulk-rounded shape at 65,88% (224 cases). At 34,12% (116 cases) it consists of a cluster of different sizes` nuclei and it does not always correspond to the shape of the ball, since in this case it may be not only round, but also have an elongated oval outline in the longitudinal direction. The plate of its gray matter has small spherical winding cogs in the shape of wavy line.

References

  1. Baumann O, Mattingley JB. Functional topography of primary emotion processing in the human cerebellum. Neuroimage. 2012 Jul 16;61(4):805-11. doi: 10.1016/j.neuroimage. 2012.03.044.
  2. Diedrichsen J. A spatially unbiased atlas template of the human cerebellum. NeuroImage. 2006 Oct 15;33(1):127-38. doi:10.1016/ j.neuroimage.2006.05.056.
  3. Cho KH, Rodríguez-Vázquez JF, Kim JH, Abe H, Murakami G, Cho BH. Early fetal development of the human cerebellum. Surg Radiol Anat. 2011 Aug;33(6):523-30. doi: 10.1007/s00276-011-0796-8.
  4. Dimitrova A, Weber J, Redies C, Kindsvater K, Maschke M, Kolb FP, Forsting M, Diener HC, Timmann D. MRI atlas of the human cerebellar nuclei. Neuroimage. 2002 Sep;17(1):240-55.
  5. Baumel Y, Jacobson GA, Cohen D. Implications of functional anatomy on information processing in the deep cerebellar nuclei. Front Cell Neurosci. 2009 Nov 20;3:14. doi: 10.3389/neuro.03.014.2009. eCollection 2009.
  6. Schindlery C, Nadvornik P, Nemecek S, Kubiasova E. [Stereotaxic model of cerebellar nuclei]. Cesk Neurol. 1964 Nov;27:370-1. Czech.
  7. Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective pro-cessing. Cortex. 2010 Jul-Aug;46(7):831-44. doi: 10.1016/j.cortex.2009.11.008.
  8. Küper M, Thürling M, Maderwald S, Ladd ME, Timmann D. Structural and functional magnetic resonance imaging of the human cerebellar nuclei. Cerebellum. 2012 Jun;11(2):314-24. doi: 10.1007/s12311-010-0194-5.
  9. Voogd J, Glickstein M. The anatomy of the cerebellum. Trends Neurosci. 1998 Sep;21(9):370-5.
  10. Dimitrova A, Zeljko D, Schwarze F, Maschke M, Gerwig M, Frings M, Beck A, Aurich V, Forsting M, Timmann D. Probabilistic 3D MRI atlas of the human cerebellar dentate/interposed nuclei. Neuroimage. 2006 Mar;30(1):12-25.
  11. Habas C. Functional imaging and the cerebellum: recent developments and challenges. Editorial. Cerebellum. 2012 Jun;11(2):311-3. doi: 10.1007/s12311-012-0375-5.
  12. Hankinson J. Stereotaxic atlas of the human brainstem and cerebellar nuclei: a variability study. J R Soc Med. 1979 Apr; 72(4): 301.
  13. Saab CY, Willis WD. The cerebellum: organization, functions and its role in nociception. Brain Res Brain Res Rev. 2003 Apr;42(1):85-95.
  14. Witter L, De Zeeuw CI, Ruigrok TJ, Hoebeek FE. The cerebellar nuclei take center stage. Cerebellum. 2011 Dec; 10(4): 633-36. doi: 10.1007/s12311-010-0245-y.
  15. Uusisaari M, De Schutter E. The mysterious microcircuitry of the cerebellar nuclei. J Physiol. 2011 Jul 15;589(Pt 14):3441-57. doi: 10.1113/jphysiol.2010.201582.
  16. Rochefort C, Lefort JM, Rondi-Reig L. The cerebellum: a new key structure in the navigation system. Front Neural Circuits. 2013 Mar 13;7:35. doi: 10.3389/fncir.2013.00035.
  17. Nadvornik P, Petr R, Nemecek S, Schindlery C, Beran J. [Topometry of the cerebellar nuclei]. Cesk Neurol. 1963 Sep;26:304-6. Czech.
  18. Shen O, Yagel S, Valsky DV, Rabinowitz R, Zalel Y. Sonographic examination of the fetal vermis: tricks for obtaining the narrow midline target with 3-dimensional volume contrast imaging in the C plane. J Ultrasound Med. 2011 Jun;30(6):827-31.
  19. Turner JW. Stereotaxic atlas of the human brainstem and cerebellar nuclei-a variability study. J Neurol Neurosurg Psychiatry. 1979 Nov;42(11):1071.
  20. Shyian DM, Korobkova LK, Lupyr VM, inventors; Kharkiv National Medical University, assignee. Method fur dyeing cerebrum preparations. Ukrainian patent UA 55427. 2010 Dec 10. Int. Cl.G01N1/30. Ukrainian.

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How to Cite

Shyian, D. N. (2016). Morphological features of the globose nucleus of the cerebellum. Морфологія / Morphologia / Morfologìâ, 10(1), 92–95. https://doi.org/10.26641/1997-9665.2016.1.92-95

Issue

Vol. 10 No. 1 (2016)

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Статті

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