Perspectives of cytomeres use in biology and medicine.

Authors

  • M. M. Fedchenko State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine
  • M. P. Fedchenko State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine
  • I. S. Shponka State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.3.39-45

Keywords:

information, structuregenesis, cytomers, proviruses, pathomorphology, infection, immunology, oncology, transplantology, exosomes

Abstract

The law of the information structuregenesis is formulated: the information transforms into interaction, interaction into connection (link), and link into a new element. There is a dependence: the more signal is structured, the more informational potential it has. At a cell-like level greatest remote informogenesis have the fragments of the cytoplasm of cells surrounded by a cell-like membrane, i.e. cytomers. These are produced by many cells and migrate in all environments of an organism. The cytomers play an important role in immunological responses, inflammation, and tumor transformation. They are the predecessors of viruses, together with which they fulfill the role of universal informational code and provide informational integration between different levels of biosphere’s life organization into the united system.The new intercellular, intertissue and interorganic regeneration mechanism by the cytomers flow from regions of high functional load to regions with minimal functional load is described. The cytomers serve as an extracellular reserve to fulfill the needs of the cytoplasm regeneration of the cells.

New pathogenetic algorithms of diseases development are based on a blockage of extravascular transport ways due to local informational (citomeric, trophical, immune etc.) deficit. A "pathogenic field" is formed because of extravasal transport ways blockage. This field limits the adaptive morphogenesis due to impossibility of structuring and proper arrangement of the informational streams.

References

  1. Avtsyn AP, Shahlamov VA. [Ultrastructural bases of cell pathology]. Moscow: Meditsina; 1979. 320 p. Russian.
  2. Ludwig AK, Giebel B. Exosomes: small vesicles participating in intercellular communication. Int J Biochem Cell Biol. 2012 Jan;44(1):11-5. doi: 10.1016/j.biocel.2011.10.005.
  3. Volkova OV, Shahlamov VA, Mironov AA, editors. [Atlas of scanning electron microscopy of cells, tissues and organs]. Moscow: Meditsina; 1987. 464 p. Russian.
  4. Fedchenko MP, Harets VI, Fedchenko MM. [The problem of structural organization of primary level of thyroid lymphatic channels]. Bulletin of problems biology and medicine. 2003;(4):48-50. Ukrainian.
  5. Arhipenko VI, Fedchenko NP. [Characteristics of the structural organization of the thyroid gland]. Arkh Anat Gistol Embriol. 1983 Dec;85(12):27-34. Russian.
  6. Fedchenko NP. Endoteliomer - novyiy formennyiy element krovi. [Endoteliomer - new blood shaped element]. Vestnik problem sovremennoi meditsiny. 1995;7:12-6. Russian.
  7. Fedchenko NP, Fedchenko NN. [Specific molecular endothelial protector was detected in vessels - a key element in providing of atraumatic shock]. In: [Proceedings of 2nd International conference "Microcirculation and its age-related changes"; 2002]. p. 320-2. Russian.
  8. Fedchenko MP, Harets' VI, Fedchenko MM. [Lipotkanel theory of the pathogenesis of atherosclerosis, paradoxes, new structural elements, rotation syndrome and lack of transport vessels]. Medical perspectives. 2002;(1):20-5. Ukrainian.
  9. Fedchenko NP, Garets VI, Fedchenko NN. [Lipotkanel theory of endothelial regeneration and pathogenesis of atherosclerosis]. In: [Proceedings of 2nd International conference "Microcirculation and its age-related changes"; 2002]. p. 317-20. Russian.
  10. Fedchenko MP, Nikitina OV. [The theoretical and pathomorphological aspects of carcinogenesis in the thyroid glands]. Medical Perspectives. 1998;(1):6-9. Ukrainian.
  11. Fedchenko NP, Fedchenko NN. [Universal pathological process and the ensuing approaches to classification and pathogenesis of some clinical entities]. In: [Abstracts of 2nd International Union Association of Pathologists; 1999]. p. 313-4. Russian.
  12. Fedchenko MM, Shpon'ka IS, Fedchenko MP, Harets' VI. [Complex pathologic diagnosis of thyroid neoplastic process: Monograph]. Dnipropetrovsk: «Serednyak T.K.»; 2012. 140 p. Ukrainian.
  13. Fedchenko NP. [A new theoretical approach to the pathogenesis of rheumatic fever and other collagenoses]. In: [Actual problems of clinical medicine: abstracts of scientifical-practical conference; 1993]. p. 50-2. Russian.
  14. Fedchenko MP. [Theoretical aspects of the pathogenesis of tuberculosis]. In: [Ecological and infectious pathology: modern pathological aspects: abstracts of 5th Congress of pathologists of Ukraine; 1993]. p. 88. Ukrainian.
  15. Fedchenko NP. [Extravascular microcirculation system theory, morphology, pathology, and prospects]. In: [Actual problems of children's diseases: materials of 7th Plenum of the Coordinating Council of the Ukrainian Association of Pathologists; 1995]. p. 83-4. Russian.
  16. Woodman PG, Futter CE. Multivesicular bodies: coordinated progression to maturity. Curr Opin Cell Biol. 2008 Aug;20(4):408-14. doi: 10.1016/j.ceb.2008.04.001.
  17. Fedchenko NP. [Secondary amyloidosis is impervious filters disease]. In: [Actual Problems of Biology and Medicine: Collection of works of DSMA; 1992]. p. 39. Russian.
  18. Fedchenko NP, Fedchenko NN [Pathomorphological philosophy, new concepts, categories, universal and general pathological process resulting from his approach to the classification and pathogenesis of some clinical entities]. In: [Materials of the conference "Innovations in pathology: theory and practice»; 1999]. p. 63-4. Russian.

Downloads

How to Cite

Fedchenko, M. M., Fedchenko, M. P., & Shponka, I. S. (2016). Perspectives of cytomeres use in biology and medicine. Морфологія / Morphologia / Morfologìâ, 10(3), 39–45. https://doi.org/10.26641/1997-9665.2016.3.39-45

Issue

Vol. 10 No. 3 (2016)

Section

Статті

License

Copyright (c) 2018 Morphologia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

 The authors reserve the right to authorship of their work and transfer to the Journal the right to the first publication of this work under the terms of a license Creative commons Attribution 4.0 International (CC BY 4.0), which allows other people to freely distribute the published work with a mandatory reference to the authors of the original work and the first publication of the work in this journal.
        By submitting a manuscript to the editorial office of the Journal ‘Morphologia’ authors agree to transfer the rights to protect and use the manuscript (all supplemental materials, particularly protected objects such as photos, drawings, diagrams, tables, etc.), including the reproduction in the press and distribution via the Internet; translation of the manuscript into any language; export and import of journal copies with the Authors’ article in order to make it available for public. Authors convey the rights mentioned above to the editorial office without any temporal or territorial limitation all over the world. 
        The Authors guarantee that they have the exclusive rights to use the material transferred to editorial office. Editors are not responsible to third parties for contraventions of warranty given by the Authors. The considered rights are transferred to the editorial office since the moment when the current issue is signed for publishing. Reproduction of materials published in the Journal by other individuals and legal entities is possible only with the consent of Editorial office, with the obligatory indication of the full bibliographic reference of the primary publication. The Authors reserve the right to use the published material, its fragments and parts for teaching materials, oral presentations, dissertation thesis prepararion with obligatory bibliographic citation of the original paper. Electron copy of the published article, downloaded from official journal web-site in .pdf format may be put by authors on the official web-site of their institutions, any other official resources with open access.