Clinical and morphological comparisons of the influence of tobacco smoke on the respiratory system of children and rats.

Authors

  • A. O. Fіalkovs'ka State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine
  • V. І. Chergіnec' State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine
  • Yu. V. Sіlkіna State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2016.4.65-69

Keywords:

teenagers, tobacco smoke, experiment

Abstract

Background. Tobacco smoking is the most common bad habit on a global scale, which is one of the main risk factors of chronic bronchopulmonary pathology. Most sensitive to exposure to the components of tobacco smoke are children and teenagers, since their respiratory system is very vulnerable through age-related functional, anatomical and morphological features. Objective. To study the depth and dynamics of morphological changes in the bronchopulmonary system of adolescents under the influence of tobacco smoke based on the comparison of clinical data and experiment on rats. Methods. There was conducted a comparative study of the influence of tobacco smoke on the respiratory system of adolescents, who were divided into 3 groups: 1 group from the earliest age were exposed to passive exposure to tobacco smoke; group 2 consisted of teenagers, whose mother during pregnancy smoked, and after being born, they continued to be subjected to passive exposure to tobacco smoke from parents; 3 group – teenagers who were active smokers, however, had not been exposed to tobacco smoke at an early age. The examination included clinical, functional and instrumental methods. The experimental part of the work was to study the morphological changes in the respiratory system of Wistar rats that were in similar conditions, in terms of load and duration of the impact of the pathological factor. Results. It is established that the level of pathological load correlates with the depth of the morphological changes. Thus, the most evident changes in the functional parameters were shown by the second group of adolescents, which coincides with the depth of disorders of the morphological structure of lung tissue of rats that were in similar conditions. The comparison of the results of clinical and experimental studies also took place in other research groups, which allowed to confirm the damaging effect of tobacco smoke on respiratory system of children and adolescents. Conclusion. Studies have shown that tobacco smoke in children and adolescents leads to morphological changes in the bronchopulmonary system, the severity of which depends on age and the duration of its exposure.

References

  1. Tyazhka OV, Vankhanova TO, Yaremenko LM. [Prevention of respiratory morbidity in preschool age children, effected by tobacco smoke because of smoking parents]. Sovremennaya pediatriya. 2014;2(58):64-69. Ukrainian.
  2. Ostrovskiy MM, Varunkiv OI. [Influence of smoking on the organs of breathing. Carpathian messenger SSS]. Pulse. 2012;4(20):55-66. Ukrainian.
  3. Jones LL, Hashim A, McKeever T, Cook DG, Britton J, Leonardi-Bee J. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systemic review and meta-analysis. Respir Res. 2011;12(5):3-11.
  4. Skachkova MA, Nikitina OV, Chainikova IN, Kaprova EG, Abubakirova AV, Tarasenko NF. [Smoking as risk factor for development diseases of the respiratory tract in children and teenagers]. Orenburg medical Bulletin. 2015;2 (10):35-38. Russian
  5. Boyko DM. [Analysis of macro-and microscopic changes in lungs of rats with experimental modeling of chronic obstructive pulmonary disease]. Herald of problems of biology and medicine. 2012;2(93): 49-53. Ukrainian.
  6. Brodskaya TA, Nevzorova VA, Gel’tser BI, Kotsyurbi EA, Agafonova IG, Luk’yanov PA. [Experimental modeling of chronic obstructive pulmonary disease of lungs with tobacco smoking and evidences of vascular dysfunction]. The Siberian scientific medical journal. 2009;1(135):60-65. Russian.
  7. Kouzoubova NА, Lebedeva ES, Dvorakovskaya IV, Platonova IS, Sourkova EA. [Peculiarities of immune reaction in development of experimental bronchopulmonary inflammation]. Herald of modern clinical medicine. 2011;4 (1):56-61. Russian.
  8. Braber S, Henricks PAJ, Nijkamp FP, Kraneveld AD, Folkerts G. Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respiratory Research; 2010:1-11.
  9. Churg A, Cosio M, Wright JL. Mechanisms of cigarette smoke-induced COPD: insights from animal models. American J Physiol Lung Cell Molecular Physiology. 2008;294:612-31.
  10. D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels RA. Time course of cigarette smoke-induced pulmonary inflammation in mice. Eur Respir J; 2005;26(2):204-13.
  11. Joos GF Cigarette smoke in mice, rats and guinea-pigs: value to the study of pathogenic factors involved in COPD. Experimental models for COPD and astma. In: 15 European respiratory congress. Copenhagen; 2005:9-38.
  12. Leberl M, Kratzer A, Taraseviciene-Stewart L. Tobacco smoke induced COPD / emphysema in the animal model – are we all on the same page? Front Physiol. 2013;4:1-23.

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How to Cite

Fіalkovs’ka A. O., Chergіnec’ V. І., & Sіlkіna Y. V. (2016). Clinical and morphological comparisons of the influence of tobacco smoke on the respiratory system of children and rats. Морфологія / Morphologia / Morfologìâ, 10(4), 65–69. https://doi.org/10.26641/1997-9665.2016.4.65-69

Issue

Vol. 10 No. 4 (2016)

Section

Статті

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