Morphological changes of anterior abdominal wall tissues in rats after implantation of alloplastic material, processed with collagen.

Authors

  • G. A. Yeroshenko Ukrainian Medical Stomatological Academy, Poltava, Ukraine
  • L. Ya. Fedonyuk I.Ya.Horbachevsky Ternopil State Medical University, Ukraine

DOI:

https://doi.org/10.26641/1997-9665.2017.2.19-24

Keywords:

polypropylene mesh, collagen, transabdominal fixation, tissue reaction.

Abstract

Background. In the area of prosthetic hernioplasty are considered the use of various materials for use in infected areas of the surgical wound, but there is no evidence base on the feasibility of using this method at present. Objective. A research purpose was to investigate the tissue reactions on implantation of polypropylene mesh, processed with collagen, after the plastic of experimental defect in rats at transabdominal localization of prosthesis. Research was performed in two experimental groups. Group 1 – at 27 rats the monofilamentous polypropylene mesh of size 1×1,5 sm was fixed transabdominal under parietal peritoneum. Group 2 – at 28 rats at analogous conditions wound the transabdominal fixation of polypropylene mesh, processed with collagen, was performed. Results. When the animals were removed from the experiment macroscopically 7 days after transabdominal plastic using a polypropylene mesh without collagen treatment in 1 of 5 rats, the formation of small adhesions with intestinal loops was observed. After 14 days, adhesion formation was noted in 2 out of 5 animals in the 1st experimental group. After application of the implant treated with collagen, in any case, no adhesion was observed. An important circumstance that determines the morphological and functional alterations of scar tissue is hemodynamic conditions that were evaluated in our study on the dynamics of changes in relative volume of hemocapillaries, surface and numerical density of the microvessels of the hemomycocirculatory bed. Dynamics of changes in the relative volume of capillaries was characterized by a clear tendency to increase during the first month of the experiment, after which a phase of decrease in values in both experimental groups occurred. Conclusion. Use of polypropylene mesh, processed with collagen, after the plastic of experimental defect in rats at transabdominal localization of prosthesis in the initially infected wounds accompanied with the acceleration of reparative processes and improvement of restructuring of connective tissue, muscular and vascular components of anterior abdominal wall during 4 weeks after intervention.

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How to Cite

Yeroshenko, G. A., & Fedonyuk, L. Y. (2017). Morphological changes of anterior abdominal wall tissues in rats after implantation of alloplastic material, processed with collagen. Морфологія / Morphologia / Morfologìâ, 11(2), 19–24. https://doi.org/10.26641/1997-9665.2017.2.19-24

Issue

Vol. 11 No. 2 (2017)

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Статті

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